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siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
Cassidy PS, Kelly RA, Reina-Torres E, Sherwood JM, Humphries MM, Kiang AS, Farrar GJ, O'Brien C, Campbell M, Stamer WD, Overby DR, Humphries P, O'Callaghan J. Cassidy PS, et al. Among authors: kelly ra. Mol Ther Methods Clin Dev. 2020 Oct 31;20:86-94. doi: 10.1016/j.omtm.2020.10.022. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33376757 Free PMC article.
Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma.
Kelly RA, Perkumas KM, Campbell M, Farrar GJ, Stamer WD, Humphries P, O'Callaghan J, O'Brien CJ. Kelly RA, et al. Int J Mol Sci. 2021 Aug 31;22(17):9446. doi: 10.3390/ijms22179446. Int J Mol Sci. 2021. PMID: 34502356 Free PMC article.
Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.
McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. McDowell CM, et al. Among authors: kelly ra. Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):12. doi: 10.1167/iovs.63.2.12. Invest Ophthalmol Vis Sci. 2022. PMID: 35129590 Free PMC article. Review.
Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology.
Li H, Kuhn M, Kelly RA, Singh A, Palanivel KK, Salama I, De Ieso ML, Stamer WD, Ganapathy PS, Herberg S. Li H, et al. Among authors: kelly ra. bioRxiv [Preprint]. 2023 Sep 9:2023.09.08.556840. doi: 10.1101/2023.09.08.556840. bioRxiv. 2023. Update in: Am J Physiol Cell Physiol. 2024 Feb 1;326(2):C513-C528. doi: 10.1152/ajpcell.00438.2023 PMID: 37781615 Free PMC article. Updated. Preprint.
Transcriptomic profiling of Schlemm's canal cells reveals a lymphatic-biased identity and three major cell states.
Balasubramanian R, Kizhatil K, Li T, Tolman N, Bhandari A, Clark G, Bupp-Chickering V, Kelly RA, Zhou S, Peregrin J, Simón M, Montgomery C, Stamer WD, Qian J, John SWM. Balasubramanian R, et al. Among authors: kelly ra. bioRxiv [Preprint]. 2024 Aug 6:2023.08.31.555823. doi: 10.1101/2023.08.31.555823. bioRxiv. 2024. Update in: Elife. 2024 Oct 18;13:RP96459. doi: 10.7554/eLife.96459 PMID: 37886472 Free PMC article. Updated. Preprint.
The Factors Affecting the Stability of IOP Homeostasis.
Overby DR, Ethier CR, Miao C, Kelly RA, Reina-Torres E, Stamer WD. Overby DR, et al. Among authors: kelly ra. Invest Ophthalmol Vis Sci. 2024 Jun 3;65(6):4. doi: 10.1167/iovs.65.6.4. Invest Ophthalmol Vis Sci. 2024. PMID: 38833261 Free PMC article.
167 results