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High-dimensional profiling of immune responses to kidney transplant reveals heterogeneous T helper 1 and B cell effectors associated with rejection.
Louis K, Tabib T, Macedo C, Wang J, Cantalupo P, Chandran U, Gu X, Lucas M, Randhawa P, Abundis M, Das J, Singh H, Lefaucheur C, Metes D. Louis K, et al. Among authors: gu x. Am J Transplant. 2024 Oct 16:S1600-6135(24)00637-3. doi: 10.1016/j.ajt.2024.10.009. Online ahead of print. Am J Transplant. 2024. PMID: 39419342
FCGR2C Q13 and FCGR3A V176 alleles jointly associate with worse natural killer cell-mediated antibody-dependent cellular cytotoxicity and microvascular inflammation in kidney allograft antibody-mediated rejection.
Bailly E, Macedo C, Gu X, Hollingshead D, Bentlejewski C, Fong E, Morel PA, Randhawa P, Zeevi A, Lefaucheur C, Metes D. Bailly E, et al. Among authors: gu x. Am J Transplant. 2024 Sep 26:S1600-6135(24)00573-2. doi: 10.1016/j.ajt.2024.09.018. Online ahead of print. Am J Transplant. 2024. PMID: 39332679
Donor-derived regulatory dendritic cell infusion results in host cell cross-dressing and T cell subset changes in prospective living donor liver transplant recipients.
Macedo C, Tran LM, Zahorchak AF, Dai H, Gu X, Ravichandran R, Mohanakumar T, Elinoff B, Zeevi A, Styn MA, Humar A, Lakkis FG, Metes DM, Thomson AW. Macedo C, et al. Among authors: gu x. Am J Transplant. 2021 Jul;21(7):2372-2386. doi: 10.1111/ajt.16393. Epub 2020 Dec 23. Am J Transplant. 2021. PMID: 33171019 Free PMC article.
Interleukin-21 promotes Type-1 activation and cytotoxicity of CD56dimCD16bright natural killer cells during kidney allograft antibody-mediated rejection showing a new link between adaptive and innate humoral allo-immunity.
Bailly E, Macedo C, Ossart J, Louis K, Gu X, Ramaswami B, Bentlejewski C, Zeevi A, Randhawa P, Lefaucheur C, Metes D. Bailly E, et al. Among authors: gu x. Kidney Int. 2023 Oct;104(4):707-723. doi: 10.1016/j.kint.2023.04.024. Epub 2023 May 21. Kidney Int. 2023. PMID: 37220805 Free PMC article.
Donor-derived regulatory dendritic cell infusion modulates effector CD8+ T cell and NK cell responses after liver transplantation.
Tran LM, Macedo C, Zahorchak AF, Gu X, Elinoff B, Singhi AD, Isett B, Zeevi A, Sykes M, Breen K, Srivastava A, Ables EM, Landsittel D, Styn MA, Humar A, Lakkis FG, Metes DM, Thomson AW. Tran LM, et al. Among authors: gu x. Sci Transl Med. 2023 Oct 11;15(717):eadf4287. doi: 10.1126/scitranslmed.adf4287. Epub 2023 Oct 11. Sci Transl Med. 2023. PMID: 37820009
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