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Novel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency.
Gechijian LN, Muncipinto G, Rettenmaier TJ, Labenski MT, Rusu V, Rosskamp L, Conway L, van Kalken D, Gross L, Iantosca G, Crotty W, Mathis R, Park H, Rabin B, Westgate C, Lyons M, Deshusses C, Brandon N, Brown DG, Blanchette HS, Pullen N, Jones LH, Barrish JC. Gechijian LN, et al. Among authors: brown dg. ACS Chem Biol. 2024 Nov 15;19(11):2372-2382. doi: 10.1021/acschembio.4c00571. Epub 2024 Oct 17. ACS Chem Biol. 2024. PMID: 39418577 Free PMC article.
Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase.
Read J, Collie IT, Nguyen-McCarty M, Lucaj C, Robinson J, Conway L, Mukherjee J, McCall E, Donohoe G, Flavell E, Peciak K, Warwicker J, Dix C, Van den Hoven BG, Madin A, Brown DG, Moss S, Haggarty SJ, Brandon NJ, Bürli RW. Read J, et al. Among authors: brown dg. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1962-1967. doi: 10.1016/j.bmcl.2019.05.032. Epub 2019 May 18. Bioorg Med Chem Lett. 2019. PMID: 31153805
Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor.
Schou M, Varnäs K, Jureus A, Ahlgren C, Malmquist J, Häggkvist J, Tari L, Wesolowski SS, Throner SR, Brown DG, Nilsson M, Johnström P, Finnema SJ, Nakao R, Amini N, Takano A, Farde L. Schou M, et al. Among authors: brown dg. ACS Chem Neurosci. 2016 Feb 17;7(2):177-84. doi: 10.1021/acschemneuro.5b00268. Epub 2015 Nov 30. ACS Chem Neurosci. 2016. PMID: 26529287
Axl receptor tyrosine kinase is a regulator of apolipoprotein E.
Zhao W, Fan J, Kulic I, Koh C, Clark A, Meuller J, Engkvist O, Barichievy S, Raynoschek C, Hicks R, Maresca M, Wang Q, Brown DG, Lok A, Parro C, Robert J, Chou HY, Zuhl AM, Wood MW, Brandon NJ, Wellington CL. Zhao W, et al. Among authors: brown dg. Mol Brain. 2020 May 4;13(1):66. doi: 10.1186/s13041-020-00609-1. Mol Brain. 2020. PMID: 32366277 Free PMC article.
398 results