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Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop.
Yu ST, Sun ZY, Li N, Qu ZZ, Wang CH, Ju TT, Liu YQ, Mei ZT, Liu KW, Lu MX, Huang M, Li Y, Dou SK, Jiang JH, Zhang YZ, Huang CH, Pang XC, Jia YQ, Dong XH, Wu F, Zhang Y, Li WH, Yang BF, Du WJ. Yu ST, et al. Among authors: dou sk. Acta Pharmacol Sin. 2024 Oct 16. doi: 10.1038/s41401-024-01395-5. Online ahead of print. Acta Pharmacol Sin. 2024. PMID: 39414959
The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury.
Qu Z, Pang X, Mei Z, Li Y, Zhang Y, Huang C, Liu K, Yu S, Wang C, Sun Z, Liu Y, Li X, Jia Y, Dong Y, Lu M, Ju T, Wu F, Huang M, Li N, Dou S, Jiang J, Dong X, Zhang Y, Li W, Yang B, Du W. Qu Z, et al. Redox Biol. 2024 Jun;72:103145. doi: 10.1016/j.redox.2024.103145. Epub 2024 Apr 2. Redox Biol. 2024. PMID: 38583415 Free PMC article.