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Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors.
Tyagarajan S, Andrews CL, Beshore DC, Buevich AV, Curran PJ, Dandliker P, Greshock TJ, Hoar J, Kim A, Karnachi P, Knemeyer I, Kozlowski J, Liu J, Maletic M, Myers R, Rada V, Sha D, Sauvagnat B, Vachal P, Wolkenberg S, Yu W, Yu Y, Krska SW. Tyagarajan S, et al. Among authors: beshore dc. ACS Med Chem Lett. 2024 Sep 12;15(10):1787-1794. doi: 10.1021/acsmedchemlett.4c00345. eCollection 2024 Oct 10. ACS Med Chem Lett. 2024. PMID: 39411537
Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.
Skudlarek JW, Cooke AJ, Mitchell HJ, Babaoglu K, Shaw AW, Tong L, Nomland AB, Labroli M, Sha D, Mulhearn JJ, Wu C, Li SW, Beshore DC, Hughes JME, Jouffroy M, Wang H, Balibar CJ, Painter RE, Shen P, Lange HS, Ishchenko A, Chen YT, Klein DJ, Tracy RW, Miller RR, Cabalu TD, Wu Z, Leithead A, Scapin G, Hruza AW, Dzhekieva L, Bukhtiyarova M, Homsher MF, Xu M, Bahnck-Teets C, McKenney D, Buevich AV, Liu J, Zhang LK, Meng T, Kelly T, DiNunzio E, Soisson S, Cheng RKY, Hennig M, Raheem I, Walker SS. Skudlarek JW, et al. Among authors: beshore dc. J Med Chem. 2024 Sep 12;67(17):15620-15675. doi: 10.1021/acs.jmedchem.4c01277. Epub 2024 Aug 22. J Med Chem. 2024. PMID: 39172133
A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Moore KP, Schwaid AG, Tudor M, Park S, Beshore DC, Converso A, Shipe WD, Anand R, Lan P, Moningka R, Rothman DM, Sun W, Chi A, Cornella-Taracido I, Adam GC, Bahnck-Teets C, Carroll SS, Fay JF, Goh SL, Lusen J, Quan S, Rodriguez S, Xu M, Andrews CL, Song C, Filzen T, Li J, Hollenstein K, Klein DJ, Lammens A, Lim UM, Fang Z, McHale C, Li Y, Lu M, Diamond TL, Howell BJ, Zuck P, Balibar CJ. Moore KP, et al. Among authors: beshore dc. ACS Chem Biol. 2022 Sep 16;17(9):2595-2604. doi: 10.1021/acschembio.2c00515. Epub 2022 Aug 31. ACS Chem Biol. 2022. PMID: 36044633
Building a Culture of Medicinal Chemistry Knowledge Sharing.
Beshore DC, Haidle AM, Arasappan A, Lim YH, Raheem I, Roecker AJ, Shockley SE, Simov V. Beshore DC, et al. J Med Chem. 2022 Mar 10;65(5):3776-3785. doi: 10.1021/acs.jmedchem.1c02144. Epub 2022 Feb 22. J Med Chem. 2022. PMID: 35192762
Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.
Beshore DC, Adam GC, Barnard RJO, Burlein C, Gallicchio SN, Holloway MK, Krosky D, Lemaire W, Myers RW, Patel S, Plotkin MA, Powell DA, Rada V, Cox CD, Coleman PJ, Klein DJ, Wolkenberg SE. Beshore DC, et al. ACS Med Chem Lett. 2021 Mar 7;12(4):540-547. doi: 10.1021/acsmedchemlett.1c00074. eCollection 2021 Apr 8. ACS Med Chem Lett. 2021. PMID: 33854701 Free PMC article.
Microbial biotransformation - an important tool for the study of drug metabolism.
Salter R, Beshore DC, Colletti SL, Evans L, Gong Y, Helmy R, Liu Y, Maciolek CM, Martin G, Pajkovic N, Phipps R, Small J, Steele J, de Vries R, Williams H, Martin IJ. Salter R, et al. Among authors: beshore dc. Xenobiotica. 2019 Aug;49(8):877-886. doi: 10.1080/00498254.2018.1512018. Epub 2018 Sep 21. Xenobiotica. 2019. PMID: 30118378
MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate.
Beshore DC, N Di Marco C, Chang RK, Greshock TJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Fuerst J, Hartman GD, Bilodeau MT, Ray WJ, Kuduk SD. Beshore DC, et al. ACS Med Chem Lett. 2018 Apr 30;9(7):652-656. doi: 10.1021/acsmedchemlett.8b00095. eCollection 2018 Jul 12. ACS Med Chem Lett. 2018. PMID: 30034595 Free PMC article.
25 results