Sotriffer C - Search Results

1

Correlating Predicted Reactivities with Experimental Inhibition Data of Covalent ChlaDUB1 Inhibitors.

Zimmermann T, Endres E, Sotriffer C, Decker M. Zimmermann T, et al. Among authors: sotriffer c. ACS Med Chem Lett. 2024 Sep 10;15(10):1708-1714. doi: 10.1021/acsmedchemlett.4c00267. eCollection 2024 Oct 10. ACS Med Chem Lett. 2024. PMID: 39411534

2

Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis.

Zimmermann T, Feng J, de Campos LJ, Knight LA, Schlötzer J, Ramirez YA, Schwickert K, Zehe M, Adler TB, Schirmeister T, Kisker C, Sotriffer C, Conda-Sheridan M, Decker M. Zimmermann T, et al. Among authors: sotriffer c. J Med Chem. 2024 Jul 11;67(13):10710-10742. doi: 10.1021/acs.jmedchem.4c00230. Epub 2024 Jun 19. J Med Chem. 2024. PMID: 38897928

3

Acetylcholinesterase inhibitors with photoswitchable inhibition of β-amyloid aggregation.

Chen X, Wehle S, Kuzmanovic N, Merget B, Holzgrabe U, König B, Sotriffer CA, Decker M. Chen X, et al. ACS Chem Neurosci. 2014 May 21;5(5):377-89. doi: 10.1021/cn500016p. Epub 2014 Mar 14. ACS Chem Neurosci. 2014. PMID: 24628027 Free PMC article.

4

Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.

Sawatzky E, Wehle S, Kling B, Wendrich J, Bringmann G, Sotriffer CA, Heilmann J, Decker M. Sawatzky E, et al. J Med Chem. 2016 Mar 10;59(5):2067-82. doi: 10.1021/acs.jmedchem.5b01674. Epub 2016 Feb 17. J Med Chem. 2016. PMID: 26886849

5

Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model.

Hoffmann M, Stiller C, Endres E, Scheiner M, Gunesch S, Sotriffer C, Maurice T, Decker M. Hoffmann M, et al. Among authors: sotriffer c. J Med Chem. 2019 Oct 24;62(20):9116-9140. doi: 10.1021/acs.jmedchem.9b01012. Epub 2019 Oct 14. J Med Chem. 2019. PMID: 31609115

6

MD-Based Assessment of Covalent Inhibitors in Noncovalent Association Complexes: Learning from Cathepsin K as a Test Case.

Endres E, Yuan Chen N, Sotriffer C. Endres E, et al. Among authors: sotriffer c. J Chem Inf Model. 2023 May 22;63(10):3186-3197. doi: 10.1021/acs.jcim.3c00061. Epub 2023 May 11. J Chem Inf Model. 2023. PMID: 37165835

7

Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.

Darras FH, Wehle S, Huang G, Sotriffer CA, Decker M. Darras FH, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4867-81. doi: 10.1016/j.bmc.2014.06.045. Epub 2014 Jul 1. Bioorg Med Chem. 2014. PMID: 25047936

8

Experimental and theoretical investigations into the stability of cyclic aminals.

Sawatzky E, Drakopoulos A, Rölz M, Sotriffer C, Engels B, Decker M. Sawatzky E, et al. Among authors: sotriffer c. Beilstein J Org Chem. 2016 Oct 31;12:2280-2292. doi: 10.3762/bjoc.12.221. eCollection 2016. Beilstein J Org Chem. 2016. PMID: 28144295 Free PMC article.

9

Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain.

Johe P, Jung S, Endres E, Kersten C, Zimmer C, Ye W, Sönnichsen C, Hellmich UA, Sotriffer C, Schirmeister T, Neuweiler H. Johe P, et al. Among authors: sotriffer c. ACS Chem Biol. 2021 Apr 16;16(4):661-670. doi: 10.1021/acschembio.0c00911. Epub 2021 Mar 15. ACS Chem Biol. 2021. PMID: 33719398

10

Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model.

He F, Chou CJ, Scheiner M, Poeta E, Yuan Chen N, Gunesch S, Hoffmann M, Sotriffer C, Monti B, Maurice T, Decker M. He F, et al. Among authors: sotriffer c. J Med Chem. 2021 Apr 8;64(7):3794-3812. doi: 10.1021/acs.jmedchem.0c01940. Epub 2021 Mar 26. J Med Chem. 2021. PMID: 33769811

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