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Page 1
Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy.
Kang TG, Lan X, Mi T, Chen H, Alli S, Lim SE, Bhatara S, Vasandan AB, Ward G, Bentivegna S, Jang J, Spatz ML, Han JH, Schlotmann BC, Jespersen JS, Derenzo C, Vogel P, Yu J, Baylin S, Jones P, O'Connell C, Grønbæk K, Youngblood B, Zebley CC. Kang TG, et al. Among authors: derenzo c. Science. 2024 Oct 11;386(6718):eadl4492. doi: 10.1126/science.adl4492. Epub 2024 Oct 11. Science. 2024. PMID: 39388542
Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial.
Hegde M, Navai S, DeRenzo C, Joseph SK, Sanber K, Wu M, Gad AZ, Janeway KA, Campbell M, Mullikin D, Nawas Z, Robertson C, Mathew PR, Zhang H, Mehta B, Bhat RR, Major A, Shree A, Gerken C, Kalra M, Chakraborty R, Thakkar SG, Dakhova O, Salsman VS, Grilley B, Lapteva N, Gee A, Dotti G, Bao R, Salem AH, Wang T, Brenner MK, Heslop HE, Wels WS, Hicks MJ, Gottschalk S, Ahmed N. Hegde M, et al. Among authors: derenzo c. Nat Cancer. 2024 Jun;5(6):880-894. doi: 10.1038/s43018-024-00749-6. Epub 2024 Apr 24. Nat Cancer. 2024. PMID: 38658775 Clinical Trial.
DNAJB1-PRKACA fusion neoantigens elicit rare endogenous T cell responses that potentiate cell therapy for fibrolamellar carcinoma.
Kirk AM, Crawford JC, Chou CH, Guy C, Pandey K, Kozlik T, Shah RK, Chung S, Nguyen P, Zhang X, Wang J, Bell M, Mettelman RC, Allen EK, Pogorelyy MV, Kim H, Minervina AA, Awad W, Bajracharya R, White T, Long D Jr, Gordon B, Morrison M, Glazer ES, Murphy AJ, Jiang Y, Fitzpatrick EA, Yarchoan M, Sethupathy P, Croft NP, Purcell AW, Federico SM, Stewart E, Gottschalk S, Zamora AE, DeRenzo C, Strome SE, Thomas PG. Kirk AM, et al. Among authors: derenzo c. Cell Rep Med. 2024 Mar 19;5(3):101469. doi: 10.1016/j.xcrm.2024.101469. Cell Rep Med. 2024. PMID: 38508137 Free PMC article.
CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity.
Haydar D, Ibañez-Vega J, Crawford JC, Chou CH, Guy CS, Meehl M, Yi Z, Perry S, Laxton J, Cunningham T, Langfitt D, Vogel P, DeRenzo C, Gottschalk S, Roussel MF, Thomas PG, Krenciute G. Haydar D, et al. Among authors: derenzo c. Cancer Res Commun. 2023 Dec 1;3(12):2430-2446. doi: 10.1158/2767-9764.CRC-23-0424. Cancer Res Commun. 2023. PMID: 37971169 Free PMC article.
CAR T-cell design dependent remodeling of the brain tumor immune microenvironment identify macrophages as key players that inhibit or promote anti-tumor activity.
Haydar D, Ibañez-Vega J, Crawford JC, Chou CH, Guy C, Meehl M, Yi Z, Langfitt D, Vogel P, DeRenzo C, Gottschalk S, Roussel MF, Thomas PG, Krenciute G. Haydar D, et al. Among authors: derenzo c. Res Sq [Preprint]. 2023 Jun 6:rs.3.rs-2972427. doi: 10.21203/rs.3.rs-2972427/v1. Res Sq. 2023. Update in: Cancer Res Commun. 2023 Dec 1;3(12):2430-2446. doi: 10.1158/2767-9764.CRC-23-0424. PMID: 37333156 Free PMC article. Updated. Preprint.
CD47 expression is critical for CAR T-cell survival in vivo.
Beckett AN, Chockley P, Pruett-Miller SM, Nguyen P, Vogel P, Sheppard H, Krenciute G, Gottschalk S, DeRenzo C. Beckett AN, et al. Among authors: derenzo c. J Immunother Cancer. 2023 Mar;11(3):e005857. doi: 10.1136/jitc-2022-005857. J Immunother Cancer. 2023. PMID: 36918226 Free PMC article.
33 results