Jenkins JL - Search Results

1

Recurrent Neurodevelopmentally Associated Variants of the Pre-mRNA Splicing Factor U2AF2 Alter RNA Binding Affinities and Interactions.

Maji D, Jenkins JL, Boutz PL, Kielkopf CL. Maji D, et al. Among authors: jenkins jl. Biochemistry. 2024 Nov 5;63(21):2718-2722. doi: 10.1021/acs.biochem.4c00344. Epub 2024 Oct 10. Biochemistry. 2024. PMID: 39388459 Free PMC article.

2

Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65.

Jenkins JL, Shen H, Green MR, Kielkopf CL. Jenkins JL, et al. J Biol Chem. 2008 Nov 28;283(48):33641-9. doi: 10.1074/jbc.M806297200. Epub 2008 Oct 8. J Biol Chem. 2008. PMID: 18842594 Free PMC article.

3

RNA induces conformational changes in the SF1/U2AF65 splicing factor complex.

Gupta A, Jenkins JL, Kielkopf CL. Gupta A, et al. Among authors: jenkins jl. J Mol Biol. 2011 Feb 4;405(5):1128-38. doi: 10.1016/j.jmb.2010.11.054. Epub 2010 Dec 10. J Mol Biol. 2011. PMID: 21146534 Free PMC article.

4

Large favorable enthalpy changes drive specific RNA recognition by RNA recognition motif proteins.

McLaughlin KJ, Jenkins JL, Kielkopf CL. McLaughlin KJ, et al. Among authors: jenkins jl. Biochemistry. 2011 Mar 8;50(9):1429-31. doi: 10.1021/bi102057m. Epub 2011 Feb 2. Biochemistry. 2011. PMID: 21261285 Free PMC article.

5

Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1.

Bauer WJ, Heath J, Jenkins JL, Kielkopf CL. Bauer WJ, et al. Among authors: jenkins jl. J Mol Biol. 2012 Jan 27;415(4):727-40. doi: 10.1016/j.jmb.2011.11.040. Epub 2011 Dec 2. J Mol Biol. 2012. PMID: 22154808 Free PMC article.

6

A Broad range of conformations contribute to the solution ensemble of the essential splicing factor U2AF(65).

Jenkins JL, Laird KM, Kielkopf CL. Jenkins JL, et al. Biochemistry. 2012 Jul 3;51(26):5223-5. doi: 10.1021/bi300277t. Epub 2012 Jun 19. Biochemistry. 2012. PMID: 22702716 Free PMC article.

7

U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.

Jenkins JL, Agrawal AA, Gupta A, Green MR, Kielkopf CL. Jenkins JL, et al. Nucleic Acids Res. 2013 Apr 1;41(6):3859-73. doi: 10.1093/nar/gkt046. Epub 2013 Feb 1. Nucleic Acids Res. 2013. PMID: 23376934 Free PMC article.

8

Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.

Agrawal AA, McLaughlin KJ, Jenkins JL, Kielkopf CL. Agrawal AA, et al. Among authors: jenkins jl. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17420-5. doi: 10.1073/pnas.1412743111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422459 Free PMC article.

9

An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.

Agrawal AA, Salsi E, Chatrikhi R, Henderson S, Jenkins JL, Green MR, Ermolenko DN, Kielkopf CL. Agrawal AA, et al. Among authors: jenkins jl. Nat Commun. 2016 Mar 8;7:10950. doi: 10.1038/ncomms10950. Nat Commun. 2016. PMID: 26952537 Free PMC article.

10

Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.

Jenkins JL, Kielkopf CL. Jenkins JL, et al. Trends Genet. 2017 May;33(5):336-348. doi: 10.1016/j.tig.2017.03.001. Epub 2017 Mar 31. Trends Genet. 2017. PMID: 28372848 Free PMC article. Review.

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