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Page 1
Third intracellular loop of HCMV US28 is necessary for signaling and viral reactivation.
Medica S, Denton M, Diggins NL, Kramer-Hansen O, Crawford LB, Mayo AT, Perez WD, Daily MA, Parkins CJ, Slind LE, Pung LJ, Weber WC, Jaeger HK, Streblow ZJ, Sulgey G, Kreklywich CN, Alexander T, Rosenkilde MM, Caposio P, Hancock MH, Streblow DN. Medica S, et al. Among authors: streblow zj. J Virol. 2024 Dec 10:e0180124. doi: 10.1128/jvi.01801-24. Online ahead of print. J Virol. 2024. PMID: 39655954 Free article.
A Covalent Chemical Probe for Chikungunya nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity.
Ghoshal A, Tse EG, Hossain MA, Asressu KH, Merten EM, Sears JD, Howell S, Perveen S, Burdick J, Morales NL, Martinez SA, Law I, Davenport BJ, Morrison TE, Streblow ZJ, Streblow DN, Mordant AL, Webb TS, Cabrera A, Herring LE, Arrowsmith CH, Pearce KH, Moorman NJ, Heise MT, Couñago RM, Brown PJ, Willson TM. Ghoshal A, et al. Among authors: streblow zj. Res Sq [Preprint]. 2024 Nov 12:rs.3.rs-5363451. doi: 10.21203/rs.3.rs-5363451/v1. Res Sq. 2024. PMID: 39606462 Free PMC article. Preprint.
Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Merten EM, Sears JD, Leisner TM, Hardy PB, Ghoshal A, Hossain MA, Asressu KH, Brown PJ, Tse EG, Stashko MA, Li K, Norris-Drouin JL, Herring LE, Mordant AL, Webb TS, Mills CA, Barker NK, Streblow ZJ, Perveen S, Arrowsmith CH, Couñago RM, Arnold JJ, Cameron CE, Streblow DN, Moorman NJ, Heise MT, Willson TM, Popov KI, Pearce KH. Merten EM, et al. Among authors: streblow zj. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2409166121. doi: 10.1073/pnas.2409166121. Epub 2024 Oct 10. Proc Natl Acad Sci U S A. 2024. PMID: 39388272
Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection.
Weber WC, Andoh TF, Kreklywich CN, Streblow ZJ, Denton M, Streblow MM, Powers JM, Sulgey G, Medica S, Dmitriev I, Curiel DT, Haese NN, Streblow DN. Weber WC, et al. Among authors: streblow zj. Vaccines (Basel). 2024 Aug 27;12(9):970. doi: 10.3390/vaccines12090970. Vaccines (Basel). 2024. PMID: 39340002 Free PMC article.
The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection.
Weber WC, Streblow ZJ, Kreklywich CN, Denton M, Sulgey G, Streblow MM, Marcano D, Flores PN, Rodriguez-Santiago RM, Alvarado LI, Rivera-Amill V, Messer WB, Hochreiter R, Kosulin K, Dubischar K, Buerger V, Streblow DN. Weber WC, et al. Among authors: streblow zj. Vaccines (Basel). 2024 Aug 7;12(8):893. doi: 10.3390/vaccines12080893. Vaccines (Basel). 2024. PMID: 39204019 Free PMC article.
Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Merten EM, Sears JD, Leisner TM, Hardy PB, Ghoshal A, Hossain MA, Asressu KH, Brown PJ, Stashko MA, Herring L, Mordant AL, Webb TS, Mills CA, Barker NK, Streblow ZJ, Perveen S, Arrowsmith C, Arnold JJ, Cameron CE, Streblow DN, Moorman NJ, Heise M, Willson TM, Popov K, Pearce KH. Merten EM, et al. Among authors: streblow zj. bioRxiv [Preprint]. 2024 May 23:2024.03.22.586341. doi: 10.1101/2024.03.22.586341. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2409166121. doi: 10.1073/pnas.2409166121 PMID: 38562906 Free PMC article. Updated. Preprint.
Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity.
Otero CE, Petkova S, Ebermann M, Taher H, John N, Hoffmann K, Davalos A, Moström MJ, Gilbride RM, Papen CR, Barber-Axthelm A, Scheef EA, Barfield R, Sprehe LM, Kendall S, Manuel TD, Vande Burgt NH, Chan C, Denton M, Streblow ZJ, Streblow DN, Hansen SG, Kaur A, Permar S, Früh K, Hengel H, Malouli D, Kolb P. Otero CE, et al. Among authors: streblow zj. bioRxiv [Preprint]. 2024 Feb 28:2024.02.27.582371. doi: 10.1101/2024.02.27.582371. bioRxiv. 2024. PMID: 38464092 Free PMC article. Preprint.
Blocking the IL-1 receptor reduces cardiac transplant ischemia and reperfusion injury and mitigates CMV-accelerated chronic rejection.
Jones IKA, Orloff S, Burg JM, Haese NN, Andoh TF, Chambers A, Fei SS, Gao L, Kreklywich CN, Streblow ZJ, Enesthvedt K, Wanderer A, Baker J, Streblow DN. Jones IKA, et al. Among authors: streblow zj. Am J Transplant. 2021 Jan;21(1):44-59. doi: 10.1111/ajt.16149. Epub 2020 Jul 18. Am J Transplant. 2021. PMID: 33405337 Free PMC article.