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Discovery of electrophilic degraders that exploit SNAr chemistry.
Zhuang Z, Byun WS, Kozicka Z, Dwyer BG, Donovan KA, Jiang Z, Jones HM, Abeja DM, Nix MN, Zhong J, Slabicki M, Fischer ES, Ebert BL, Gray NS. Zhuang Z, et al. Among authors: dwyer bg. bioRxiv [Preprint]. 2024 Sep 27:2024.09.25.615094. doi: 10.1101/2024.09.25.615094. bioRxiv. 2024. PMID: 39386645 Free PMC article. Preprint.
Relocalizing transcriptional kinases to activate apoptosis.
Sarott RC, Gourisankar S, Karim B, Nettles S, Yang H, Dwyer BG, Simanauskaite JM, Tse J, Abuzaid H, Krokhotin A, Zhang T, Hinshaw SM, Green MR, Crabtree GR, Gray NS. Sarott RC, et al. Among authors: dwyer bg. Science. 2024 Oct 4;386(6717):eadl5361. doi: 10.1126/science.adl5361. Epub 2024 Oct 4. Science. 2024. PMID: 39361741
Borrowing Transcriptional Kinases to Activate Apoptosis.
Sarott R, Gourisankar S, Karim B, Nettles S, Yang H, Dwyer BG, Simanauskaite JM, Tse J, Abuzaid H, Krokhotin A, Zhang T, Hinshaw SM, Green MR, Crabtree GR, Gray NS. Sarott R, et al. Among authors: dwyer bg. bioRxiv [Preprint]. 2023 Oct 25:2023.10.23.563687. doi: 10.1101/2023.10.23.563687. bioRxiv. 2023. Update in: Science. 2024 Oct 4;386(6717):eadl5361. doi: 10.1126/science.adl5361. PMID: 37961702 Free PMC article. Updated. Preprint.
Total Synthesis and Target Identification of the Curcusone Diterpenes.
Cui C, Dwyer BG, Liu C, Abegg D, Cai ZJ, Hoch DG, Yin X, Qiu N, Liu JQ, Adibekian A, Dai M. Cui C, et al. Among authors: dwyer bg. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11. J Am Chem Soc. 2021. PMID: 33705657 Free PMC article.
The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules.
Wang ZF, Ursu A, Childs-Disney JL, Guertler R, Yang WY, Bernat V, Rzuczek SG, Fuerst R, Zhang YJ, Gendron TF, Yildirim I, Dwyer BG, Rice JE, Petrucelli L, Disney MD. Wang ZF, et al. Among authors: dwyer bg. Cell Chem Biol. 2019 Feb 21;26(2):179-190.e12. doi: 10.1016/j.chembiol.2018.10.018. Epub 2018 Nov 29. Cell Chem Biol. 2019. PMID: 30503283 Free PMC article.
12 results