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CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.
Skoulidis F, Araujo HA, Do MT, Qian Y, Sun X, Cobo AG, Le JT, Montesion M, Palmer R, Jahchan N, Juan JM, Min C, Yu Y, Pan X, Arbour KC, Vokes N, Schmidt ST, Molkentine D, Owen DH, Memmott R, Patil PD, Marmarelis ME, Awad MM, Murray JC, Hellyer JA, Gainor JF, Dimou A, Bestvina CM, Shu CA, Riess JW, Blakely CM, Pecot CV, Mezquita L, Tabbó F, Scheffler M, Digumarthy S, Mooradian MJ, Sacher AG, Lau SCM, Saltos AN, Rotow J, Johnson RP, Liu C, Stewart T, Goldberg SB, Killam J, Walther Z, Schalper K, Davies KD, Woodcock MG, Anagnostou V, Marrone KA, Forde PM, Ricciuti B, Venkatraman D, Van Allen EM, Cummings AL, Goldman JW, Shaish H, Kier M, Katz S, Aggarwal C, Ni Y, Azok JT, Segal J, Ritterhouse L, Neal JW, Lacroix L, Elamin YY, Negrao MV, Le X, Lam VK, Lewis WE, Kemp HN, Carter B, Roth JA, Swisher S, Lee R, Zhou T, Poteete A, Kong Y, Takehara T, Paula AG, Parra Cuentas ER, Behrens C, Wistuba II, Zhang J, Blumenschein GR, Gay C, Byers LA, Gibbons DL, Tsao A, Lee JJ, Bivona TG, Camidge DR, Gray JE, Lieghl N, Levy B, Brahmer JR, Garassino MC, Gandara DR, Garon EB, Rizvi NA, Scagliotti GV, Wolf J, Planchard D, Besse B, Herbst RS, Wakelee HA, Pennell NA, Shaw AT, Jänne PA, Carbone DP, Hellm… See abstract for full author list ➔ Skoulidis F, et al. Among authors: winslow mm. Nature. 2024 Oct 9. doi: 10.1038/s41586-024-07943-7. Online ahead of print. Nature. 2024. PMID: 39385035
Experimental variables determine the outcome of RAS-RAS interactions.
Zhou Z, Nguyen TL, Li X, Poujol C, Berlinska E, Michelina SV, Kapp JN, Plückthun A, Winslow MM, Ambrogio C, Shan Y, Santamaría D, Westover KD. Zhou Z, et al. Among authors: winslow mm. J Biol Chem. 2024 Oct 5:107859. doi: 10.1016/j.jbc.2024.107859. Online ahead of print. J Biol Chem. 2024. PMID: 39374781 Free article.
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis.
Ashkin EL, Tang YJ, Xu H, Hung KL, Belk J, Cai H, Lopez S, Dolcen DN, Hebert JD, Li R, Ruiz PA, Keal T, Andrejka L, Chang HY, Petrov DA, Dixon JR, Xu Z, Winslow MM. Ashkin EL, et al. Among authors: winslow mm. bioRxiv [Preprint]. 2024 Sep 19:2024.09.14.613043. doi: 10.1101/2024.09.14.613043. bioRxiv. 2024. PMID: 39345539 Free PMC article. Preprint.
Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network.
Boutelle AM, Mabene AR, Yao D, Xu H, Wang M, Tang YJ, Lopez SS, Sinha S, Demeter J, Cheng R, Benard BA, Valente LJ, Drainas AP, Fischer M, Majeti R, Petrov DA, Jackson PK, Yang F, Winslow MM, Bassik MC, Attardi LD. Boutelle AM, et al. Among authors: winslow mm. bioRxiv [Preprint]. 2024 Sep 18:2024.09.17.612743. doi: 10.1101/2024.09.17.612743. bioRxiv. 2024. PMID: 39345444 Free PMC article. Preprint.
Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes.
Tang YJ, Xu H, Hughes NW, Kim SH, Ruiz P, Shuldiner EG, Lopez SS, Hebert JD, Karmakar S, Andrejka L, Dolcen DN, Boross G, Chu P, Detrick C, Pierce S, Ashkin EL, Greenleaf WJ, Voss AK, Thomas T, van de Rijn M, Petrov DA, Winslow MM. Tang YJ, et al. Among authors: winslow mm. bioRxiv [Preprint]. 2024 Aug 20:2024.08.19.607671. doi: 10.1101/2024.08.19.607671. bioRxiv. 2024. PMID: 39229041 Free PMC article. Preprint.
Aging represses lung tumorigenesis and alters tumor suppression.
Shuldiner EG, Karmakar S, Tsai MK, Hebert JD, Tang YJ, Andrejka L, Wang M, Detrick CR, Cai H, Tang R, Petrov DA, Winslow MM. Shuldiner EG, et al. Among authors: winslow mm. bioRxiv [Preprint]. 2024 May 31:2024.05.28.596319. doi: 10.1101/2024.05.28.596319. bioRxiv. 2024. PMID: 38853826 Free PMC article. Preprint.
Efficient and multiplexed somatic genome editing with Cas12a mice.
Hebert JD, Xu H, Tang YJ, Ruiz PA, Detrick CR, Wang J, Hughes NW, Donosa O, Andrejka L, Karmakar S, Aboiralor I, Tang R, Sage J, Cong L, Petrov DA, Winslow MM. Hebert JD, et al. Among authors: winslow mm. bioRxiv [Preprint]. 2024 May 25:2024.03.07.583774. doi: 10.1101/2024.03.07.583774. bioRxiv. 2024. PMID: 38496463 Free PMC article. Preprint.
A Lung Cancer Mouse Model Database.
Cai L, Gao Y, DeBerardinis RJ, Acquaah-Mensah G, Aidinis V, Beane JE, Biswal S, Chen T, Concepcion-Crisol CP, Grüner BM, Jia D, Jones R, Kurie JM, Lee MG, Lindahl P, Lissanu Y, Lorz Lopez MC, Martinelli R, Mazur PK, Mazzilli SA, Mii S, Moll H, Moorehead R, Morrisey EE, Ng SR, Oser MG, Pandiri AR, Powell CA, Ramadori G, Santos Lafuente M, Snyder E, Sotillo R, Su KY, Taki T, Taparra K, Xia Y, van Veen E, Winslow MM, Xiao G, Rudin CM, Oliver TG, Xie Y, Minna JD. Cai L, et al. Among authors: winslow mm. bioRxiv [Preprint]. 2024 May 14:2024.02.28.582577. doi: 10.1101/2024.02.28.582577. bioRxiv. 2024. PMID: 38464291 Free PMC article. Preprint.
Oncogenic context shapes the fitness landscape of tumor suppression.
Blair LM, Juan JM, Sebastian L, Tran VB, Nie W, Wall GD, Gerceker M, Lai IK, Apilado EA, Grenot G, Amar D, Foggetti G, Do Carmo M, Ugur Z, Deng D, Chenchik A, Paz Zafra M, Dow LE, Politi K, MacQuitty JJ, Petrov DA, Winslow MM, Rosen MJ, Winters IP. Blair LM, et al. Among authors: winslow mm. Nat Commun. 2023 Oct 12;14(1):6422. doi: 10.1038/s41467-023-42156-y. Nat Commun. 2023. PMID: 37828026 Free PMC article.
97 results