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Transcriptional coactivator MED15 is required for beta cell maturation.
Kadhim AZ, Vanderkruk B, Mar S, Dan M, Zosel K, Xu EE, Spencer RJ, Sasaki S, Cheng X, Sproul SLJ, Speckmann T, Nian C, Cullen R, Shi R, Luciani DS, Hoffman BG, Taubert S, Lynn FC. Kadhim AZ, et al. Among authors: luciani ds. Nat Commun. 2024 Oct 8;15(1):8711. doi: 10.1038/s41467-024-52801-9. Nat Commun. 2024. PMID: 39379383 Free PMC article.
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Skovsø S, et al. Among authors: luciani ds. Nat Commun. 2022 Feb 8;13(1):735. doi: 10.1038/s41467-022-28039-8. Nat Commun. 2022. PMID: 35136059 Free PMC article.
Cellular metabolism constrains innate immune responses in early human ontogeny.
Kan B, Michalski C, Fu H, Au HHT, Lee K, Marchant EA, Cheng MF, Anderson-Baucum E, Aharoni-Simon M, Tilley P, Mirmira RG, Ross CJ, Luciani DS, Jan E, Lavoie PM. Kan B, et al. Among authors: luciani ds. Nat Commun. 2018 Nov 16;9(1):4822. doi: 10.1038/s41467-018-07215-9. Nat Commun. 2018. PMID: 30446641 Free PMC article.
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.
Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, Lin Y, Townsend RR, Polonsky KS, Johnson JD. Jeffrey KD, et al. Among authors: luciani ds. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8452-7. doi: 10.1073/pnas.0711232105. Epub 2008 Jun 11. Proc Natl Acad Sci U S A. 2008. PMID: 18550819 Free PMC article.
36 results