Leuzzi G - Search Results

1

Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap.

Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu X, Costa JA, Pezet MG, Chou J, Snoeck HW, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT. Gu J, et al. Among authors: leuzzi g. Nat Biotechnol. 2024 Oct 7. doi: 10.1038/s41587-024-02386-x. Online ahead of print. Nat Biotechnol. 2024. PMID: 39375448

2

Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant.

Nambiar TS, Billon P, Diedenhofen G, Hayward SB, Taglialatela A, Cai K, Huang JW, Leuzzi G, Cuella-Martin R, Palacios A, Gupta A, Egli D, Ciccia A. Nambiar TS, et al. Among authors: leuzzi g. Nat Commun. 2019 Jul 30;10(1):3395. doi: 10.1038/s41467-019-11105-z. Nat Commun. 2019. PMID: 31363085 Free PMC article.

3

HATtracting Nucleases to Stalled Forks.

Leuzzi G, Taglialatela A, Ciccia A. Leuzzi G, et al. Mol Cell. 2020 Oct 15;80(2):177-180. doi: 10.1016/j.molcel.2020.09.031. Mol Cell. 2020. PMID: 33065018 Free article.

4

Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens.

Walsh ZH, Shah P, Kothapalli N, Shah SB, Nikolenyi G, Brodtman DZ, Leuzzi G, Rogava M, Mu M, Ho P, Abuzaid S, Vasan N, AlQuraishi M, Milner JD, Ciccia A, Melms JC, Izar B. Walsh ZH, et al. Among authors: leuzzi g. Nat Biotechnol. 2024 May 23. doi: 10.1038/s41587-024-02235-x. Online ahead of print. Nat Biotechnol. 2024. PMID: 38783148

5

MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.

Huang JW, Acharya A, Taglialatela A, Nambiar TS, Cuella-Martin R, Leuzzi G, Hayward SB, Joseph SA, Brunette GJ, Anand R, Soni RK, Clark NL, Bernstein KA, Cejka P, Ciccia A. Huang JW, et al. Among authors: leuzzi g. Nat Commun. 2020 Jun 11;11(1):2948. doi: 10.1038/s41467-020-16718-3. Nat Commun. 2020. PMID: 32528060 Free PMC article.

6

Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease.

Joseph SA, Taglialatela A, Leuzzi G, Huang JW, Cuella-Martin R, Ciccia A. Joseph SA, et al. Among authors: leuzzi g. DNA Repair (Amst). 2020 Nov;95:102943. doi: 10.1016/j.dnarep.2020.102943. Epub 2020 Aug 15. DNA Repair (Amst). 2020. PMID: 32971328 Free PMC article. Review.

7

Functional interrogation of DNA damage response variants with base editing screens.

Cuella-Martin R, Hayward SB, Fan X, Chen X, Huang JW, Taglialatela A, Leuzzi G, Zhao J, Rabadan R, Lu C, Shen Y, Ciccia A. Cuella-Martin R, et al. Among authors: leuzzi g. Cell. 2021 Feb 18;184(4):1081-1097.e19. doi: 10.1016/j.cell.2021.01.041. Cell. 2021. PMID: 33606978 Free PMC article.

8

REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.

Taglialatela A, Leuzzi G, Sannino V, Cuella-Martin R, Huang JW, Wu-Baer F, Baer R, Costanzo V, Ciccia A. Taglialatela A, et al. Among authors: leuzzi g. Mol Cell. 2021 Oct 7;81(19):4008-4025.e7. doi: 10.1016/j.molcel.2021.08.016. Epub 2021 Sep 10. Mol Cell. 2021. PMID: 34508659 Free PMC article.

9

Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia.

Conte MI, Poli MC, Taglialatela A, Leuzzi G, Chinn IK, Salinas SA, Rey-Jurado E, Olivares N, Veramendi-Espinoza L, Ciccia A, Lupski JR, Aldave Becerra JC, Mace EM, Orange JS. Conte MI, et al. Among authors: leuzzi g. JCI Insight. 2022 Nov 8;7(21):e154948. doi: 10.1172/jci.insight.154948. JCI Insight. 2022. PMID: 36345943 Free PMC article.

10

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.

Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang JW, Madubata C, Anand R, Levy B, Rabadan R, Cejka P, Costanzo V, Ciccia A. Taglialatela A, et al. Among authors: leuzzi g. Mol Cell. 2017 Oct 19;68(2):414-430.e8. doi: 10.1016/j.molcel.2017.09.036. Mol Cell. 2017. PMID: 29053959 Free PMC article.

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