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Large-scale multi-omic analysis identifies noncoding somatic driver mutations and nominates ZFP36L2 as a driver gene for pancreatic ductal adenocarcinoma.
Zhong J, O'Brien A, Patel M, Eiser D, Mobaraki M, Collins I, Wang L, Guo K, TruongVo T, Jermusyk A, O'Neill M, Dill CD, Wells AD, Leonard ME, Pippin JA, Grant SFA, Zhang T, Andresson T, Connelly KE, Shi J, Arda HE, Hoskins JW, Amundadottir LT. Zhong J, et al. Among authors: wells ad. medRxiv [Preprint]. 2024 Sep 24:2024.09.22.24314165. doi: 10.1101/2024.09.22.24314165. medRxiv. 2024. PMID: 39371173 Free PMC article. Preprint.
Variant-to-function mapping of late-onset Alzheimer's disease GWAS signals in human microglial cell models implicates RTFDC1 at the CASS4 locus.
Burton EA, Argenziano M, Cook K, Ridler M, Lu S, Su C, Manduchi E, Littleton SH, Leonard ME, Hodge KM, Wang LS, Schellenberg GD, Johnson ME, Pahl MC, Pippin JA, Wells AD, Anderson SA, Brown CD, Grant SFA, Chesi A. Burton EA, et al. Among authors: wells ad. bioRxiv [Preprint]. 2024 Aug 22:2024.08.22.609230. doi: 10.1101/2024.08.22.609230. bioRxiv. 2024. PMID: 39229212 Free PMC article. Preprint.
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.
Trang KB, Sharma P, Cook L, Mount Z, Thomas RM, Kulkarni NN, Pahl MC, Pippin JA, Su C, Kaestner KH, O'Brien JM, Wagley Y, Hankenson KD, Jermusyk A, Hoskins JW, Amundadottir LT, Xu M, Brown KM, Anderson SA, Yang W, Titchenell PM, Seale P, Zemel BS, Chesi A, Romberg N, Levings MK, Grant SFA, Wells AD. Trang KB, et al. Among authors: wells ad. medRxiv [Preprint]. 2024 Aug 12:2024.08.12.24311676. doi: 10.1101/2024.08.12.24311676. medRxiv. 2024. PMID: 39185517 Free PMC article. Preprint.
Shared and unique 3D genomic features of substance use disorders across multiple cell types.
Trang KB, Chesi A, Toikumo S, Pippin JA, Pahl MC, O'Brien JM, Amundadottir LT, Brown KM, Yang W, Welles J, Santoleri D, Titchenell PM, Seale P, Zemel BS, Wagley Y, Hankenson KD, Kaestner KH, Anderson SA, Kayser MS, Wells AD, Kranzler HR, Kember RL, Grant SFA. Trang KB, et al. Among authors: wells ad. medRxiv [Preprint]. 2024 Jul 19:2024.07.18.24310649. doi: 10.1101/2024.07.18.24310649. medRxiv. 2024. PMID: 39072016 Free PMC article. Preprint.
Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2.
Littleton SH, Trang KB, Volpe CM, Cook K, DeBruyne N, Maguire JA, Weidekamp MA, Hodge KM, Boehm K, Lu S, Chesi A, Bradfield JP, Pippin JA, Anderson SA, Wells AD, Pahl MC, Grant SFA. Littleton SH, et al. Among authors: wells ad. Cell Genom. 2024 May 8;4(5):100556. doi: 10.1016/j.xgen.2024.100556. Epub 2024 May 1. Cell Genom. 2024. PMID: 38697123 Free PMC article.
The common variable immunodeficiency IgM repertoire narrowly recognizes erythrocyte and platelet glycans.
Le Coz C, Trofa M, Butler DL, Yoon S, Tian T, Reid W, Cruz Cabrera E, Knox AVC, Khanna C, Sullivan KE, Heimall J, Takach P, Fadugba OO, Lawrence M, Jyonouchi S, Hakonarson H, Wells AD, Handler S, Zur KB, Pillai V, Gildersleeve JC, Romberg N. Le Coz C, et al. Among authors: wells ad. J Allergy Clin Immunol. 2024 Sep;154(3):778-791.e9. doi: 10.1016/j.jaci.2024.04.018. Epub 2024 Apr 29. J Allergy Clin Immunol. 2024. PMID: 38692308
Osteoporosis GWAS-implicated DNM3 locus contextually regulates osteoblastic and chondrogenic fate of mesenchymal stem/progenitor cells through oscillating miR-199a-5p levels.
Kaur G, Pippin JA, Chang S, Redmond J, Chesi A, Wells AD, Maerz T, Grant SFA, Coleman RM, Hankenson KD, Wagley Y. Kaur G, et al. Among authors: wells ad. JBMR Plus. 2024 Apr 10;8(5):ziae051. doi: 10.1093/jbmrpl/ziae051. eCollection 2024 May. JBMR Plus. 2024. PMID: 38686038 Free PMC article.
153 results