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AAV-mediated genome editing is influenced by the formation of R-loops.
Puzzo F, Crossley MP, Goswami A, Zhang F, Pekrun K, Garzon JL, Cimprich KA, Kay MA. Puzzo F, et al. Among authors: pekrun k. Mol Ther. 2024 Dec 4;32(12):4256-4271. doi: 10.1016/j.ymthe.2024.09.035. Epub 2024 Oct 5. Mol Ther. 2024. PMID: 39369271
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors.
Suchy FP, Karigane D, Nakauchi Y, Higuchi M, Zhang J, Pekrun K, Hsu I, Fan AC, Nishimura T, Charlesworth CT, Bhadury J, Nishimura T, Wilkinson AC, Kay MA, Majeti R, Nakauchi H. Suchy FP, et al. Among authors: pekrun k. Nat Biotechnol. 2024 Apr 8:10.1038/s41587-024-02171-w. doi: 10.1038/s41587-024-02171-w. Online ahead of print. Nat Biotechnol. 2024. PMID: 38589662
A strategy for high antibody expression with low anti-drug antibodies using AAV9 vectors.
Davis-Gardner ME, Weber JA, Xie J, Pekrun K, Alexander EA, Weisgrau KL, Furlott JR, Rakasz EG, Kay MA, Gao G, Farzan M, Gardner MR. Davis-Gardner ME, et al. Among authors: pekrun k. Front Immunol. 2023 Apr 21;14:1105617. doi: 10.3389/fimmu.2023.1105617. eCollection 2023. Front Immunol. 2023. PMID: 37153616 Free PMC article.
Improved Genome Editing through Inhibition of FANCM and Members of the BTR Dissolvase Complex.
de Alencastro G, Puzzo F, Pavel-Dinu M, Zhang F, Pillay S, Majzoub K, Tiffany M, Jang H, Sheikali A, Cromer MK, Meetei R, Carette JE, Porteus MH, Pekrun K, Kay MA. de Alencastro G, et al. Among authors: pekrun k. Mol Ther. 2021 Mar 3;29(3):1016-1027. doi: 10.1016/j.ymthe.2020.10.020. Epub 2020 Oct 22. Mol Ther. 2021. PMID: 33678249 Free PMC article.
21 results