Arkinson C - Search Results

1

Structural landscape of AAA+ ATPase motor states in the substrate-degrading human 26S proteasome reveals conformation-specific binding of TXNL1.

Arkinson C, Gee CL, Zhang Z, Dong KC, Martin A. Arkinson C, et al. bioRxiv [Preprint]. 2024 Nov 9:2024.11.08.622731. doi: 10.1101/2024.11.08.622731. bioRxiv. 2024. PMID: 39574680 Free PMC article. Preprint.

2

Mechanisms and regulation of substrate degradation by the 26S proteasome.

Arkinson C, Dong KC, Gee CL, Martin A. Arkinson C, et al. Nat Rev Mol Cell Biol. 2024 Oct 3. doi: 10.1038/s41580-024-00778-0. Online ahead of print. Nat Rev Mol Cell Biol. 2024. PMID: 39362999 Review.

3

Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.

Rennie ML, Gundogdu M, Arkinson C, Liness S, Frame S, Walden H. Rennie ML, et al. Among authors: arkinson c. J Med Chem. 2024 Sep 12;67(17):15557-15568. doi: 10.1021/acs.jmedchem.4c01184. Epub 2024 Aug 27. J Med Chem. 2024. PMID: 39190802 Free PMC article.

4

Nub1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome.

Arkinson C, Dong KC, Gee CL, Costello SM, Marqusee S, Martin A. Arkinson C, et al. bioRxiv [Preprint]. 2024 Jun 12:2024.06.12.598715. doi: 10.1101/2024.06.12.598715. bioRxiv. 2024. PMID: 38915702 Free PMC article. Preprint.

5

Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCF^β-Trcp1-dependent ubiquitylation of the actin-organizing protein Dbn1.

Colding-Christensen CS, Kakulidis ES, Arroyo-Gomez J, Hendriks IA, Arkinson C, Fábián Z, Gambus A, Mailand N, Duxin JP, Nielsen ML. Colding-Christensen CS, et al. Among authors: arkinson c. Nat Commun. 2023 Dec 14;14(1):8293. doi: 10.1038/s41467-023-43873-0. Nat Commun. 2023. PMID: 38097601 Free PMC article.

6

Preparation of site-specifically fluorophore-labeled polyubiquitin chains for FRET studies of Cdc48 substrate processing.

Williams C, Dong KC, Arkinson C, Martin A. Williams C, et al. Among authors: arkinson c. STAR Protoc. 2023 Dec 15;4(4):102659. doi: 10.1016/j.xpro.2023.102659. Epub 2023 Oct 26. STAR Protoc. 2023. PMID: 37889757 Free PMC article.

7

The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48.

Williams C, Dong KC, Arkinson C, Martin A. Williams C, et al. Among authors: arkinson c. Mol Cell. 2023 Mar 2;83(5):759-769.e7. doi: 10.1016/j.molcel.2023.01.016. Epub 2023 Feb 2. Mol Cell. 2023. PMID: 36736315 Free PMC article.

8

Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.

Lemonidis K, Rennie ML, Arkinson C, Chaugule VK, Clarke M, Streetley J, Walden H. Lemonidis K, et al. Among authors: arkinson c. EMBO J. 2023 Feb 1;42(3):e111898. doi: 10.15252/embj.2022111898. Epub 2022 Nov 17. EMBO J. 2023. PMID: 36385258 Free PMC article.

9

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.

Rennie ML, Arkinson C, Chaugule VK, Walden H. Rennie ML, et al. Among authors: arkinson c. Sci Adv. 2022 Sep 30;8(39):eabq6353. doi: 10.1126/sciadv.abq6353. Epub 2022 Sep 28. Sci Adv. 2022. PMID: 36170365 Free PMC article.

10

Mechanism, specificity, and function of FANCD2-FANCI ubiquitination and deubiquitination.

Lemonidis K, Arkinson C, Rennie ML, Walden H. Lemonidis K, et al. Among authors: arkinson c. FEBS J. 2022 Aug;289(16):4811-4829. doi: 10.1111/febs.16077. Epub 2021 Jun 29. FEBS J. 2022. PMID: 34137174 Free article. Review.

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