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A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import.
Boulay A, Quevarec E, Malet I, Nicastro G, Chamontin C, Perrin S, Henriquet C, Pugnière M, Courgnaud V, Blaise M, Marcelin AG, Taylor IA, Chaloin L, Arhel NJ. Boulay A, et al. Among authors: pugniere m. EMBO Mol Med. 2024 Nov;16(11):2918-2945. doi: 10.1038/s44321-024-00143-w. Epub 2024 Oct 2. EMBO Mol Med. 2024. PMID: 39358603 Free PMC article.
Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating.
Fernandez J, Machado AK, Lyonnais S, Chamontin C, Gärtner K, Léger T, Henriquet C, Garcia C, Portilho DM, Pugnière M, Chaloin L, Muriaux D, Yamauchi Y, Blaise M, Nisole S, Arhel NJ. Fernandez J, et al. Among authors: pugniere m. Nat Microbiol. 2019 Nov;4(11):1840-1850. doi: 10.1038/s41564-019-0575-6. Epub 2019 Oct 14. Nat Microbiol. 2019. PMID: 31611641
A method to confer Protein L binding ability to any antibody fragment.
Lakhrif Z, Pugnière M, Henriquet C, di Tommaso A, Dimier-Poisson I, Billiald P, Juste MO, Aubrey N. Lakhrif Z, et al. Among authors: pugniere m. MAbs. 2016;8(2):379-88. doi: 10.1080/19420862.2015.1116657. Epub 2015 Dec 18. MAbs. 2016. PMID: 26683650 Free PMC article.
CCSP counterbalances airway epithelial-driven neutrophilic chemotaxis.
Knabe L, Petit A, Vernisse C, Charriot J, Pugnière M, Henriquet C, Sasorith S, Molinari N, Chanez P, Berthet JP, Suehs C, Vachier I, Ahmed E, Bourdin A. Knabe L, et al. Among authors: pugniere m. Eur Respir J. 2019 Jul 11;54(1):1802408. doi: 10.1183/13993003.02408-2018. Print 2019 Jul. Eur Respir J. 2019. PMID: 31023848 Free article. Clinical Trial.
101 results