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A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import.
Boulay A, Quevarec E, Malet I, Nicastro G, Chamontin C, Perrin S, Henriquet C, Pugnière M, Courgnaud V, Blaise M, Marcelin AG, Taylor IA, Chaloin L, Arhel NJ. Boulay A, et al. Among authors: nicastro g. EMBO Mol Med. 2024 Nov;16(11):2918-2945. doi: 10.1038/s44321-024-00143-w. Epub 2024 Oct 2. EMBO Mol Med. 2024. PMID: 39358603 Free PMC article.
KH-RNA interactions: back in the groove.
Nicastro G, Taylor IA, Ramos A. Nicastro G, et al. Curr Opin Struct Biol. 2015 Feb;30:63-70. doi: 10.1016/j.sbi.2015.01.002. Epub 2015 Jan 24. Curr Opin Struct Biol. 2015. PMID: 25625331 Review.
Structural basis for Fullerene geometry in a human endogenous retrovirus capsid.
Acton O, Grant T, Nicastro G, Ball NJ, Goldstone DC, Robertson LE, Sader K, Nans A, Ramos A, Stoye JP, Taylor IA, Rosenthal PB. Acton O, et al. Among authors: nicastro g. Nat Commun. 2019 Dec 20;10(1):5822. doi: 10.1038/s41467-019-13786-y. Nat Commun. 2019. PMID: 31862888 Free PMC article.
Structure of a Spumaretrovirus Gag Central Domain Reveals an Ancient Retroviral Capsid.
Ball NJ, Nicastro G, Dutta M, Pollard DJ, Goldstone DC, Sanz-Ramos M, Ramos A, Müllers E, Stirnnagel K, Stanke N, Lindemann D, Stoye JP, Taylor WR, Rosenthal PB, Taylor IA. Ball NJ, et al. Among authors: nicastro g. PLoS Pathog. 2016 Nov 9;12(11):e1005981. doi: 10.1371/journal.ppat.1005981. eCollection 2016 Nov. PLoS Pathog. 2016. PMID: 27829070 Free PMC article.
HIV-1 capsid is involved in post-nuclear entry steps.
Chen NY, Zhou L, Gane PJ, Opp S, Ball NJ, Nicastro G, Zufferey M, Buffone C, Luban J, Selwood D, Diaz-Griffero F, Taylor I, Fassati A. Chen NY, et al. Among authors: nicastro g. Retrovirology. 2016 Apr 23;13:28. doi: 10.1186/s12977-016-0262-0. Retrovirology. 2016. PMID: 27107820 Free PMC article.
Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis.
Nicastro G, García-Mayoral MF, Hollingworth D, Kelly G, Martin SR, Briata P, Gherzi R, Ramos A. Nicastro G, et al. Nat Struct Mol Biol. 2012 Dec;19(12):1282-6. doi: 10.1038/nsmb.2427. Epub 2012 Nov 11. Nat Struct Mol Biol. 2012. PMID: 23142982 Free PMC article.
Mechanism of β-actin mRNA Recognition by ZBP1.
Nicastro G, Candel AM, Uhl M, Oregioni A, Hollingworth D, Backofen R, Martin SR, Ramos A. Nicastro G, et al. Cell Rep. 2017 Jan 31;18(5):1187-1199. doi: 10.1016/j.celrep.2016.12.091. Cell Rep. 2017. PMID: 28147274 Free PMC article.
70 results