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Page 1
Substrate recognition principles for the PP2A-B55 protein phosphatase.
Kruse T, Garvanska DH, Varga JK, Garland W, McEwan BC, Hein JB, Weisser MB, Benavides-Puy I, Chan CB, Sotelo-Parrilla P, Mendez BL, Jeyaprakash AA, Schueler-Furman O, Jensen TH, Kettenbach AN, Nilsson J. Kruse T, et al. Among authors: mcewan bc. Sci Adv. 2024 Oct 4;10(40):eadp5491. doi: 10.1126/sciadv.adp5491. Epub 2024 Oct 2. Sci Adv. 2024. PMID: 39356758 Free PMC article.
Substrate recognition principles for the PP2A-B55 protein phosphatase.
Kruse T, Garvanska DH, Varga J, Garland W, McEwan B, Hein JB, Weisser MB, Puy IB, Chan CB, Parrila PS, Mendez BL, Arulanandam J, Schueler-Furman O, Jensen TH, Kettenbach A, Nilsson J. Kruse T, et al. bioRxiv [Preprint]. 2024 Feb 13:2024.02.10.579793. doi: 10.1101/2024.02.10.579793. bioRxiv. 2024. Update in: Sci Adv. 2024 Oct 4;10(40):eadp5491. doi: 10.1126/sciadv.adp5491 PMID: 38370611 Free PMC article. Updated. Preprint.
Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061.
Vit G, Duro J, Rajendraprasad G, Hertz EPT, Holland LKK, Weisser MB, McEwan BC, Lopez-Mendez B, Sotelo-Parrilla P, Jeyaprakash AA, Montoya G, Mailand N, Maeda K, Kettenbach A, Barisic M, Nilsson J. Vit G, et al. Among authors: mcewan bc. EMBO J. 2022 Jul 18;41(14):e110611. doi: 10.15252/embj.2022110611. Epub 2022 Jun 13. EMBO J. 2022. PMID: 35695070 Free PMC article.
FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs.
Wasserman JS, Faezov B, Patel KR, Kurimchak AM, Palacio SM, Glass DJ, Fowle H, McEwan BC, Xu Q, Zhao Z, Cressey L, Johnson N, Duncan JS, Kettenbach AN, Dunbrack RL Jr, Graña X. Wasserman JS, et al. Among authors: mcewan bc. Nat Commun. 2024 Jul 10;15(1):5776. doi: 10.1038/s41467-024-50015-7. Nat Commun. 2024. PMID: 38982062 Free PMC article.
FAM122A ensures cell cycle interphase progression and checkpoint control as a SLiM-dependent substrate-competitive inhibitor to the B55⍺/PP2A phosphatase.
Wasserman JS, Faezov B, Patel KR, Kurimchak AN, Palacio SM, Fowle H, McEwan BC, Xu Q, Zhao Z, Cressey L, Johnson N, Duncan JS, Kettenbach AN, Dunbrack RL, Graña X. Wasserman JS, et al. Among authors: mcewan bc. bioRxiv [Preprint]. 2023 Mar 17:2023.03.06.531310. doi: 10.1101/2023.03.06.531310. bioRxiv. 2023. PMID: 36945596 Free PMC article. Preprint.