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Page 1
Optimizing the detection of N-nitrosamine mutagenicity in the Ames test.
Heflich RH, Bishop ME, Mittelstaedt RA, Yan J, Guerrero SK, Sims AM, Mitchell K, Moore N, Li X, Mei N, Elespuru RK, King ST, Keire DA, Kruhlak NL, Dorsam RT, Raw AS, Davis Bruno KL, McGovern TJ, Atrakchi AH. Heflich RH, et al. Among authors: davis bruno kl. Regul Toxicol Pharmacol. 2024 Nov;153:105709. doi: 10.1016/j.yrtph.2024.105709. Epub 2024 Sep 28. Regul Toxicol Pharmacol. 2024. PMID: 39343352
Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays.
Li X, Le Y, Seo JE, Guo X, Li Y, Chen S, Mittelstaedt RA, Moore N, Guerrero S, Sims A, King ST, Atrakchi AH, McGovern TJ, Davis-Bruno KL, Keire DA, Elespuru RK, Heflich RH, Mei N. Li X, et al. Among authors: davis bruno kl. Regul Toxicol Pharmacol. 2023 Jun;141:105410. doi: 10.1016/j.yrtph.2023.105410. Epub 2023 May 18. Regul Toxicol Pharmacol. 2023. PMID: 37210026 Free PMC article.
Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of four small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities.
Guo X, Seo JE, Xu H, Yan J, Malhi P, Atrakchi AH, Mcgovern T, Davis Bruno KL, Heflich RH, Chen T. Guo X, et al. Among authors: davis bruno kl. Toxicol Sci. 2025 Jan 3:kfaf002. doi: 10.1093/toxsci/kfaf002. Online ahead of print. Toxicol Sci. 2025. PMID: 39752321
An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs).
Avila AM, Bebenek I, Bonzo JA, Bourcier T, Davis Bruno KL, Carlson DB, Dubinion J, Elayan I, Harrouk W, Lee SL, Mendrick DL, Merrill JC, Peretz J, Place E, Saulnier M, Wange RL, Yao J, Zhao D, Brown PC. Avila AM, et al. Among authors: davis bruno kl. Regul Toxicol Pharmacol. 2020 Jul;114:104662. doi: 10.1016/j.yrtph.2020.104662. Epub 2020 Apr 20. Regul Toxicol Pharmacol. 2020. PMID: 32325112
Thromboxane A2 receptors.
Halushka PV, Allan CJ, Davis-Bruno KL. Halushka PV, et al. Among authors: davis bruno kl. J Lipid Mediat Cell Signal. 1995 Oct;12(2-3):361-78. doi: 10.1016/0929-7855(95)00023-j. J Lipid Mediat Cell Signal. 1995. PMID: 8777579 Review. No abstract available.