PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17-cell differentiation and regulating cytokine production.
Liu H, Wan C, Ding Y, Han R, He Y, Xiao J, Hao J.
Liu H, et al.
FASEB J. 2017 Apr;31(4):1756-1766. doi: 10.1096/fj.201601147R. Epub 2017 Jan 17.
FASEB J. 2017.
PMID: 28096232
Furthermore, reduction of STAT3 phosphorylation may have directly suppressed T(h)17-cell differentiation. Therefore, our study demonstrates that PR-957 could potently alleviate inflammation in rats with EAN and that it may be a likely candidate for treating Guillain-Barre …
Furthermore, reduction of STAT3 phosphorylation may have directly suppressed T(h)17-cell differentiation. Therefore, our study demons …