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Designed endocytosis-inducing proteins degrade targets and amplify signals.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Tang C, Wang R, Schlichthaerle T, Zhang JZ, Wang Y, Goreshnik I, Chiu CW, Chazin-Gray A, Chan S, Gerben S, Murray A, Wang S, O'Neill J, Yi L, Yeh R, Misquith A, Wolf A, Tomasovic LM, Piraner DI, Duran Gonzalez MJ, Bennett NR, Venkatesh P, Ahlrichs M, Dobbins C, Yang W, Wang X, Sahtoe DD, Vafeados D, Mout R, Shivaei S, Cao L, Carter L, Stewart L, Spangler JB, Roybal KT, Greisen PJ, Li X, Bernardes GJL, Bertozzi CR, Baker D. Huang B, et al. Among authors: wang x, wang y, wang s, wang r. Nature. 2024 Sep 25. doi: 10.1038/s41586-024-07948-2. Online ahead of print. Nature. 2024. PMID: 39322662
Designed Endocytosis-Triggering Proteins mediate Targeted Degradation.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Wang R, Schlichthaerle T, Zhang JZ, Wang Y, Goreshnik I, Chiu CW, Chazin-Gray A, Chan S, Gerben S, Murray A, Wang S, O'Neill J, Yeh R, Misquith A, Wolf A, Tomasovic LM, Piraner DI, Gonzalez MJD, Bennett NR, Venkatesh P, Satoe D, Ahlrichs M, Dobbins C, Yang W, Wang X, Vafeados D, Mout R, Shivaei S, Cao L, Carter L, Stewart L, Spangler JB, Bernardes GJL, Roybal KT, Greisen P Jr, Li X, Bertozzi C, Baker D. Huang B, et al. Among authors: wang x, wang y, wang s, wang r. bioRxiv [Preprint]. 2023 Sep 20:2023.08.19.553321. doi: 10.1101/2023.08.19.553321. bioRxiv. 2023. PMID: 37781607 Free PMC article. Preprint.
Molecular basis of V-ATPase inhibition by bafilomycin A1.
Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X. Wang R, et al. Among authors: wang j. Nat Commun. 2021 Mar 19;12(1):1782. doi: 10.1038/s41467-021-22111-5. Nat Commun. 2021. PMID: 33741963 Free PMC article.
Cryo-EM structures of intact V-ATPase from bovine brain.
Wang R, Long T, Hassan A, Wang J, Sun Y, Xie XS, Li X. Wang R, et al. Among authors: wang j. Nat Commun. 2020 Aug 6;11(1):3921. doi: 10.1038/s41467-020-17762-9. Nat Commun. 2020. PMID: 32764564 Free PMC article.
Structure and mechanism of human cystine exporter cystinosin.
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X. Guo X, et al. Among authors: wang r. Cell. 2022 Sep 29;185(20):3739-3752.e18. doi: 10.1016/j.cell.2022.08.020. Epub 2022 Sep 15. Cell. 2022. PMID: 36113465 Free PMC article.
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