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Symmetry of loop extrusion by dimeric SMC complexes is DNA-tension-dependent.
Pradhan B, Pinto A, Kanno T, Tetiker D, Baaske MD, Cutt E, Chatzicharlampous C, Schüler H, Deep A, Corbett KD, Aragon L, Virnau P, Björkegren C, Kim E. Pradhan B, et al. Among authors: kim e. bioRxiv [Preprint]. 2024 Sep 12:2024.09.12.612694. doi: 10.1101/2024.09.12.612694. bioRxiv. 2024. PMID: 39314301 Free PMC article. Preprint.
Condensin-driven loop extrusion on supercoiled DNA.
Kim E, Gonzalez AM, Pradhan B, van der Torre J, Dekker C. Kim E, et al. Nat Struct Mol Biol. 2022 Jul;29(7):719-727. doi: 10.1038/s41594-022-00802-x. Epub 2022 Jul 14. Nat Struct Mol Biol. 2022. PMID: 35835864
SMC complexes can traverse physical roadblocks bigger than their ring size.
Pradhan B, Barth R, Kim E, Davidson IF, Bauer B, van Laar T, Yang W, Ryu JK, van der Torre J, Peters JM, Dekker C. Pradhan B, et al. Among authors: kim e. Cell Rep. 2022 Oct 18;41(3):111491. doi: 10.1016/j.celrep.2022.111491. Cell Rep. 2022. PMID: 36261017 Free article.
The Smc5/6 complex is a DNA loop-extruding motor.
Pradhan B, Kanno T, Umeda Igarashi M, Loke MS, Baaske MD, Wong JSK, Jeppsson K, Björkegren C, Kim E. Pradhan B, et al. Among authors: kim e. Nature. 2023 Apr;616(7958):843-848. doi: 10.1038/s41586-023-05963-3. Epub 2023 Apr 19. Nature. 2023. PMID: 37076626 Free PMC article.
Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils.
Jeppsson K, Pradhan B, Sutani T, Sakata T, Umeda Igarashi M, Berta DG, Kanno T, Nakato R, Shirahige K, Kim E, Björkegren C. Jeppsson K, et al. Among authors: kim e. Mol Cell. 2024 Mar 7;84(5):867-882.e5. doi: 10.1016/j.molcel.2024.01.005. Epub 2024 Jan 30. Mol Cell. 2024. PMID: 38295804 Free article.
Molecular mechanism of condensin I activation by KIF4A.
Cutts EE, Tetiker D, Kim E, Aragon L. Cutts EE, et al. Among authors: kim e. EMBO J. 2024 Dec 17. doi: 10.1038/s44318-024-00340-w. Online ahead of print. EMBO J. 2024. PMID: 39690239 Free article.
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