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Page 1
Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation.
Kwaku GN, Jensen KN, Simaku P, Floyd DJ, Saelens JW, Reardon CM, Ward RA, Basham KJ, Hepworth OW, Vyas TD, Zamith-Miranda D, Nosanchuk JD, Vyas JM, Harding HB. Kwaku GN, et al. Among authors: simaku p. bioRxiv [Preprint]. 2025 Jan 3:2025.01.03.631181. doi: 10.1101/2025.01.03.631181. bioRxiv. 2025. PMID: 39803513 Free PMC article. Preprint.
Single-cell analysis of human airway epithelium identifies cell type-specific responses to Aspergillus and Coccidioides.
Harding AT, Crossen AJ, Reedy JL, Basham KJ, Hepworth OW, Zhang Y, Shah VS, Harding HB, Surve MV, Simaku P, Kwaku GN, Jensen KN, Otto Y, Ward RA, Thompson GR, Klein BS, Rajagopal J, Sen P, Haber AL, Vyas JM. Harding AT, et al. Among authors: simaku p. bioRxiv [Preprint]. 2024 Sep 13:2024.09.09.612147. doi: 10.1101/2024.09.09.612147. bioRxiv. 2024. PMID: 39314271 Free PMC article. Preprint.
BTK inhibitor-induced defects in human neutrophil effector activity against Aspergillus fumigatus are restored by TNF-α.
Vargas-Blanco DA, Hepworth OW, Basham KJ, Simaku P, Crossen AJ, Timmer KD, Hopke A, Brown Harding H, Vandal SR, Jensen KN, Floyd DJ, Reedy JL, Reardon C, Mansour MK, Ward RA, Irimia D, Abramson JS, Vyas JM. Vargas-Blanco DA, et al. Among authors: simaku p. JCI Insight. 2024 May 7;9(12):e176162. doi: 10.1172/jci.insight.176162. JCI Insight. 2024. PMID: 38713531 Free PMC article.
Fungal melanin suppresses airway epithelial chemokine secretion through blockade of calcium fluxing.
Reedy JL, Jensen KN, Crossen AJ, Basham KJ, Ward RA, Reardon CM, Harding HB, Hepworth OW, Simaku P, Kwaku GN, Tone K, Willment JA, Reid DM, Stappers MHT, Brown GD, Rajagopal J, Vyas JM. Reedy JL, et al. Among authors: simaku p. bioRxiv [Preprint]. 2024 May 6:2023.03.28.534632. doi: 10.1101/2023.03.28.534632. bioRxiv. 2024. Update in: Nat Commun. 2024 Jul 10;15(1):5817. doi: 10.1038/s41467-024-50100-x PMID: 37034634 Free PMC article. Updated. Preprint.