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Page 1
CDS2 expression regulates de novo phosphatidic acid synthesis.
Collins DM, Janardan V, Barneda D, Anderson KE, Niewczas I, Taylor D, Qiu D, Jessen HJ, Lopez-Clavijo AF, Walker S, Raghu P, Clark J, Stephens LR, Hawkins PT. Collins DM, et al. Among authors: stephens lr. Biochem J. 2024 Oct 16;481(20):1449-1473. doi: 10.1042/BCJ20240456. Biochem J. 2024. PMID: 39312194 Free PMC article.
The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling.
Chan V, Camardi C, Zhang K, Orofiamma LA, Anderson KE, Hoque J, Bone LN, Awadeh Y, Lee DKC, Fu NJ, Chow JTS, Salmena L, Stephens LR, Hawkins PT, Antonescu CN, Botelho RJ. Chan V, et al. Among authors: stephens lr. Mol Biol Cell. 2024 Sep 1;35(9):ar118. doi: 10.1091/mbc.E23-09-0361. Epub 2024 Jul 18. Mol Biol Cell. 2024. PMID: 39024272 Free PMC article.
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate.
Chessa TAM, Jung P, Anwar A, Suire S, Anderson KE, Barneda D, Kielkowska A, Sadiq BA, Lai IW, Felisbino S, Turnham DJ, Pearson HB, Phillips WA, Sasaki J, Sasaki T, Oxley D, Spensberger D, Segonds-Pichon A, Wilson M, Walker S, Okkenhaug H, Cosulich S, Hawkins PT, Stephens LR. Chessa TAM, et al. Among authors: stephens lr. Mol Cell. 2023 Aug 17;83(16):2991-3009.e13. doi: 10.1016/j.molcel.2023.07.015. Epub 2023 Aug 10. Mol Cell. 2023. PMID: 37567175 Free article.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B. Gong GQ, et al. Among authors: stephens lr. Nature. 2023 Jun;618(7963):159-168. doi: 10.1038/s41586-023-05972-2. Epub 2023 May 24. Nature. 2023. PMID: 37225977 Free PMC article.
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase.
Walpole GFW, Pacheco J, Chauhan N, Clark J, Anderson KE, Abbas YM, Brabant-Kirwan D, Montaño-Rendón F, Liu Z, Zhu H, Brumell JH, Deiters A, Stephens LR, Hawkins PT, Hammond GRV, Grinstein S, Fairn GD. Walpole GFW, et al. Among authors: stephens lr. Nat Cell Biol. 2022 May;24(5):708-722. doi: 10.1038/s41556-022-00895-y. Epub 2022 Apr 28. Nat Cell Biol. 2022. PMID: 35484249 Free PMC article.
128 results