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Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity.
Herrmann A, Gege C, Wangen C, Wagner S, Kögler M, Cordsmeier A, Irrgang P, Ip WH, Weil T, Hunszinger V, Groß R, Heinen N, Pfaender S, Reuter S, Klopfleisch R, Uhlig N, Eberlein V, Issmail L, Grunwald T, Hietel B, Cynis H, Münch J, Sparrer KMJ, Ensser A, Tenbusch M, Dobner T, Vitt D, Kohlhof H, Hahn F. Herrmann A, et al. Among authors: sparrer kmj. Antiviral Res. 2024 Nov;231:106008. doi: 10.1016/j.antiviral.2024.106008. Epub 2024 Sep 19. Antiviral Res. 2024. PMID: 39306285 Free article.
A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1.
Freisem D, Rodriguez-Alfonso AA, Lawrenz J, Zhou Z, Monecke T, Preising N, Endres S, Wiese S, Ständker L, Kuan SL, Thal DR, Weil T, Niessing D, Barth H, Kirchhoff F, Harms M, Münch J, Sparrer KMJ. Freisem D, et al. Among authors: sparrer kmj. Cell Mol Life Sci. 2024 Sep 17;81(1):409. doi: 10.1007/s00018-024-05447-1. Cell Mol Life Sci. 2024. PMID: 39289189 Free PMC article.
Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens.
Groß R, Reßin H, von Maltitz P, Albers D, Schneider L, Bley H, Hoffmann M, Cortese M, Gupta D, Deniz M, Choi JY, Jansen J, Preußer C, Seehafer K, Pöhlmann S, Voelker DR, Goffinet C, Pogge-von Strandmann E, Bunz U, Bartenschlager R, El Andaloussi S, Sparrer KMJ, Herker E, Becker S, Kirchhoff F, Münch J, Müller JA. Groß R, et al. Among authors: sparrer kmj. Nat Microbiol. 2024 Apr;9(4):905-921. doi: 10.1038/s41564-024-01637-6. Epub 2024 Mar 25. Nat Microbiol. 2024. PMID: 38528146 Free PMC article.
Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques.
Laliberté A, Prelli Bozzo C, Stahl-Hennig C, Hunszinger V, Joas S, Sauermann U, Roshani B, Klippert A, Daskalaki M, Mätz-Rensing K, Stolte-Leeb N, Tharp GK, Fuchs D, Gupta PM, Silvestri G, Nelson SA, Parodi L, Giavedoni L, Bosinger SE, Sparrer KMJ, Kirchhoff F. Laliberté A, et al. Among authors: sparrer kmj. iScience. 2023 Oct 26;26(12):108351. doi: 10.1016/j.isci.2023.108351. eCollection 2023 Dec 15. iScience. 2023. PMID: 38025783 Free PMC article.
CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins.
Hoenigsperger H, Koepke L, Acharya D, Hunszinger V, Freisem D, Grenzner A, Wiese S, Kirchhoff F, Gack MU, Sparrer KMJ. Hoenigsperger H, et al. Among authors: sparrer kmj. Autophagy. 2024 May;20(5):994-1014. doi: 10.1080/15548627.2023.2281128. Epub 2023 Nov 17. Autophagy. 2024. PMID: 37938186 Free PMC article.
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ. Hirschenberger M, et al. Among authors: sparrer kmj. Nat Commun. 2023 Nov 1;14(1):6770. doi: 10.1038/s41467-023-42150-4. Nat Commun. 2023. PMID: 37914730 Free PMC article.
Regulation of STING activity in DNA sensing by ISG15 modification.
Lin C, Kuffour EO, Fuchs NV, Gertzen CGW, Kaiser J, Hirschenberger M, Tang X, Xu HC, Michel O, Tao R, Haase A, Martin U, Kurz T, Drexler I, Görg B, Lang PA, Luedde T, Sparrer KMJ, Gohlke H, König R, Münk C. Lin C, et al. Among authors: sparrer kmj. Cell Rep. 2023 Nov 28;42(11):113277. doi: 10.1016/j.celrep.2023.113277. Epub 2023 Oct 20. Cell Rep. 2023. PMID: 37864791 Free article.
63 results