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Page 1
Spatiotemporal EP4-fibulin-1 expression is associated with vascular intimal hyperplasia.
Okumura S, Oka S, Sasaki T, Cooley MA, Hidaka Y, Inoue H, Nishijima H, Ohno SI, Tanifuji S, Kaneko M, Abe T, Kuroda M, Yokosuka T, Breyer RM, Homma H, Kato Y, Yokoyama U. Okumura S, et al. Among authors: breyer rm. Cardiovasc Res. 2024 Sep 22:cvae211. doi: 10.1093/cvr/cvae211. Online ahead of print. Cardiovasc Res. 2024. PMID: 39305517
Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.
Bosma KJ, Andrei SR, Katz LS, Smith AA, Dunn JC, Ricciardi VF, Ramirez MA, Baumel-Alterzon S, Pace WA, Carroll DT, Overway EM, Wolf EM, Kimple ME, Sheng Q, Scott DK, Breyer RM, Gannon M. Bosma KJ, et al. Among authors: breyer rm. Mol Metab. 2021 Dec;54:101347. doi: 10.1016/j.molmet.2021.101347. Epub 2021 Oct 6. Mol Metab. 2021. PMID: 34626853 Free PMC article.
Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion.
Sandhu HK, Neuman JC, Schaid MD, Davis SE, Connors KM, Challa R, Guthery E, Fenske RJ, Patibandla C, Breyer RM, Kimple ME. Sandhu HK, et al. Among authors: breyer rm. Pharmacol Res Perspect. 2021 Apr;9(2):e00736. doi: 10.1002/prp2.736. Pharmacol Res Perspect. 2021. PMID: 33694300 Free PMC article.
Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells.
Crittenden S, Goepp M, Pollock J, Robb CT, Smyth DJ, Zhou Y, Andrews R, Tyrrell V, Gkikas K, Adima A, O'Connor RA, Davies L, Li XF, Yao HX, Ho GT, Zheng X, Mair A, Vermeren S, Qian BZ, Mole DJ, Gerasimidis K, Schwarze JKJ, Breyer RM, Arends MJ, O'Donnell VB, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Rossi AG, Howie SE, Yao C. Crittenden S, et al. Among authors: breyer rm. Sci Adv. 2021 Feb 12;7(7):eabd7954. doi: 10.1126/sciadv.abd7954. Print 2021 Feb. Sci Adv. 2021. PMID: 33579710 Free PMC article.
Niacin ameliorates ulcerative colitis via prostaglandin D2 -mediated D prostanoid receptor 1 activation.
Li J, Kong D, Wang Q, Wu W, Tang Y, Bai T, Guo L, Wei L, Zhang Q, Yu Y, Qian Y, Zuo S, Liu G, Liu Q, Wu S, Zang Y, Zhu Q, Jia D, Wang Y, Yao W, Ji Y, Yin H, Nakamura M, Lazarus M, Breyer RM, Wang L, Yu Y. Li J, et al. Among authors: breyer rm. EMBO Mol Med. 2020 Dec 7;12(12):e13487. doi: 10.15252/emmm.202013487. EMBO Mol Med. 2020. PMID: 33285043 Free PMC article.
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.
Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, Frommelt LS, Qu R, Knapp MS, Henriques A, Chalkidi N, Koliaraki V, Jiao J, Brewer JR, Bacher M, Blackburn HN, Zhao X, Breyer RM, Aidinis V, Jain D, Su B, Herschman HR, Kluger Y, Kollias G, Flavell RA. Roulis M, et al. Among authors: breyer rm. Nature. 2020 Apr;580(7804):524-529. doi: 10.1038/s41586-020-2166-3. Epub 2020 Apr 1. Nature. 2020. PMID: 32322056 Free PMC article.
Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation.
Hiromi T, Yokoyama U, Kurotaki D, Mamun A, Ishiwata R, Ichikawa Y, Nishihara H, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Takeuchi I, Masuda M, Breyer RM, Tamura T, Ishikawa Y. Hiromi T, et al. Among authors: breyer rm. Arterioscler Thromb Vasc Biol. 2020 Jun;40(6):1559-1573. doi: 10.1161/ATVBAHA.120.314297. Epub 2020 Apr 23. Arterioscler Thromb Vasc Biol. 2020. PMID: 32321307 Free PMC article.
Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
He Y, Zuo C, Jia D, Bai P, Kong D, Chen D, Liu G, Li J, Wang Y, Chen G, Yan S, Xiao B, Zhang J, Piao L, Li Y, Deng Y, Li B, Roux PP, Andreasson KI, Breyer RM, Su Y, Wang J, Lyu A, Shen Y, Yu Y. He Y, et al. Among authors: breyer rm. Am J Respir Crit Care Med. 2020 May 15;201(10):1263-1276. doi: 10.1164/rccm.201911-2137OC. Am J Respir Crit Care Med. 2020. PMID: 31917615 Free PMC article.
130 results