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BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors.
Judd AS, Bawa B, Buck WR, Tao ZF, Li Y, Mitten MJ, Bruncko M, Catron N, Doherty G, Durbin KR, Enright B, Frey R, Haasch D, Haman S, Haight AR, Henriques TA, Holms J, Izeradjene K, Judge RA, Jenkins GJ, Kunzer A, Leverson JD, Martin RL, Mitra D, Mittelstadt S, Nelson L, Nimmer P, Palma J, Peterson R, Phillips DC, Ralston SL, Rosenberg SH, Shen X, Song X, Vaidya KS, Wang X, Wang J, Xiao Y, Zhang H, Zhang X, Blomme EA, Boghaert ER, Kalvass JC, Phillips A, Souers AJ. Judd AS, et al. Among authors: frey r. Sci Adv. 2024 Oct 4;10(40):eado7120. doi: 10.1126/sciadv.ado7120. Epub 2024 Oct 4. Sci Adv. 2024. PMID: 39365864 Free PMC article.
Discovery of Potent Azetidine-Benzoxazole MerTK Inhibitors with In Vivo Target Engagement.
Frey RR, Jana N, Gorman JV, Wang J, Smith HA, Bromberg KD, Thakur A, Doktor SZ, Indulkar AS, Jakob CG, Upadhyay AK, Qiu W, Manaves V, Gambino F Jr, Valentino SA, Montgomery D, Zhou Y, Li T, Buchanan FG, Ferguson DC, Kurnick MD, Kapecki N, Lai A, Michaelides MR, Penning TD. Frey RR, et al. J Med Chem. 2024 Oct 10;67(19):17033-17052. doi: 10.1021/acs.jmedchem.4c01451. Epub 2024 Sep 30. J Med Chem. 2024. PMID: 39350472
Squeezing the quantum noise of a gravitational-wave detector below the standard quantum limit.
Jia W, Xu V, Kuns K, Nakano M, Barsotti L, Evans M, Mavalvala N; members of the LIGO Scientific Collaboration†; Abbott R, Abouelfettouh I, Adhikari RX, Ananyeva A, Appert S, Arai K, Aritomi N, Aston SM, Ball M, Ballmer SW, Barker D, Berger BK, Betzwieser J, Bhattacharjee D, Billingsley G, Bode N, Bonilla E, Bossilkov V, Branch A, Brooks AF, Brown DD, Bryant J, Cahillane C, Cao H, Capote E, Chen Y, Clara F, Collins J, Compton CM, Cottingham R, Coyne DC, Crouch R, Csizmazia J, Cullen TJ, Dartez LP, Demos N, Dohmen E, Driggers JC, Dwyer SE, Effler A, Ejlli A, Etzel T, Feicht J, Frey R, Frischhertz W, Fritschel P, Frolov VV, Fulda P, Fyffe M, Ganapathy D, Gateley B, Giaime JA, Giardina KD, Glanzer J, Goetz E, Goodwin-Jones AW, Gras S, Gray C, Griffith D, Grote H, Guidry T, Hall ED, Hanks J, Hanson J, Heintze MC, Helmling-Cornell AF, Huang HY, Inoue Y, James AL, Jennings A, Karat S, Kasprzack M, Kawabe K, Kijbunchoo N, Kissel JS, Kontos A, Kumar R, Landry M, Lantz B, Laxen M, Lee K, Lesovsky M, Llamas F, Lormand M, Loughlin HA, Macas R, MacInnis M, Makarem CN, Mannix B, Mansell GL, Martin RM, Maxwell N, McCarrol G, McCarthy R, McClelland DE, McCormick S, McCuller L, McRae T, Mer… See abstract for full author list ➔ Jia W, et al. Among authors: frey r. Science. 2024 Sep 20;385(6715):1318-1321. doi: 10.1126/science.ado8069. Epub 2024 Sep 19. Science. 2024. PMID: 39298573
Discovery of A-910, a Highly Potent and Orally Bioavailable Dual MerTK/Axl-Selective Tyrosine Kinase Inhibitor.
Yu Y, Jang M, Miyashiro J, Clark RF, Zhu GD, Gong J, Dai Y, Frey RR, Penning TD, Kim H, Lee HK, Kim JK, Ryu KM, Park SJ, Yoon T, Li T, Kurnick MD, Kapecki NJ, Li L, Gorman JV, Montgomery DA, Manaves V, Bromberg KD, Doktor SZ, Thakur A, Wang J, Smith HA, Buchanan FG, Ferguson DC, Torrent M, Jakob CG, Qiu W, Upadhyay AK, Martin RL, Lai A, Michaelides MR. Yu Y, et al. Among authors: frey rr. J Med Chem. 2024 Oct 10;67(19):17000-17032. doi: 10.1021/acs.jmedchem.4c01450. Epub 2024 Sep 16. J Med Chem. 2024. PMID: 39283694
1,005 results