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Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities.
Oleksak P, Rysanek D, Vancurova M, Vasicova P, Urbancokova A, Novak J, Maurencova D, Kashmel P, Houserova J, Mikyskova R, Novotny O, Reinis M, Juda P, Hons M, Kroupova J, Sedlak D, Sulimenko T, Draber P, Chlubnova M, Nepovimova E, Kuca K, Lisa M, Andrys R, Kobrlova T, Soukup O, Janousek J, Prchal L, Bartek J, Musilek K, Hodny Z. Oleksak P, et al. Among authors: sedlak d. ACS Pharmacol Transl Sci. 2024 Aug 12;7(9):2755-2783. doi: 10.1021/acsptsci.4c00190. eCollection 2024 Sep 13. ACS Pharmacol Transl Sci. 2024. PMID: 39296273
Estradiol dimer inhibits tubulin polymerization and microtubule dynamics.
Jurášek M, Černohorská M, Řehulka J, Spiwok V, Sulimenko T, Dráberová E, Darmostuk M, Gurská S, Frydrych I, Buriánová R, Ruml T, Hajdúch M, Bartůněk P, Dráber P, Džubák P, Drašar PB, Sedlák D. Jurášek M, et al. Among authors: sedlak d. J Steroid Biochem Mol Biol. 2018 Oct;183:68-79. doi: 10.1016/j.jsbmb.2018.05.008. Epub 2018 May 24. J Steroid Biochem Mol Biol. 2018. PMID: 29803726
Silychristin: Skeletal Alterations and Biological Activities.
Biedermann D, Buchta M, Holečková V, Sedlák D, Valentová K, Cvačka J, Bednárová L, Křenková A, Kuzma M, Škuta C, Peikerová Ž, Bartůněk P, Křen V. Biedermann D, et al. Among authors: sedlak d. J Nat Prod. 2016 Dec 23;79(12):3086-3092. doi: 10.1021/acs.jnatprod.6b00750. Epub 2016 Nov 22. J Nat Prod. 2016. PMID: 28006905
Unique peptidic agonists of a juvenile hormone receptor with species-specific effects on insect development and reproduction.
Tumova S, Milacek M, Šnajdr I, Muthu M, Tuma R, Reha D, Jedlicka P, Bittova L, Novotna A, Majer P, Sedlak D, Jindra M. Tumova S, et al. Among authors: sedlak d. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2215541119. doi: 10.1073/pnas.2215541119. Epub 2022 Nov 21. Proc Natl Acad Sci U S A. 2022. PMID: 36409882 Free PMC article.
235 results