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Page 1
Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects.
Konecny J, Misiachna A, Chvojkova M, Kleteckova L, Kolcheva M, Novak M, Prchal L, Ladislav M, Hemelikova K, Netolicky J, Hrabinova M, Kobrlova T, Karasova JZ, Pejchal J, Fibigar J, Vecera Z, Kucera T, Jendelova P, Zahumenska P, Langore E, Doderovic J, Pang YP, Vales K, Korabecny J, Soukup O, Horak M. Konecny J, et al. Among authors: kobrlova t. Eur J Med Chem. 2024 Dec 15;280:116981. doi: 10.1016/j.ejmech.2024.116981. Epub 2024 Oct 18. Eur J Med Chem. 2024. PMID: 39442339 Free article.
Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities.
Oleksak P, Rysanek D, Vancurova M, Vasicova P, Urbancokova A, Novak J, Maurencova D, Kashmel P, Houserova J, Mikyskova R, Novotny O, Reinis M, Juda P, Hons M, Kroupova J, Sedlak D, Sulimenko T, Draber P, Chlubnova M, Nepovimova E, Kuca K, Lisa M, Andrys R, Kobrlova T, Soukup O, Janousek J, Prchal L, Bartek J, Musilek K, Hodny Z. Oleksak P, et al. Among authors: kobrlova t. ACS Pharmacol Transl Sci. 2024 Aug 12;7(9):2755-2783. doi: 10.1021/acsptsci.4c00190. eCollection 2024 Sep 13. ACS Pharmacol Transl Sci. 2024. PMID: 39296273
Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation.
Novak M, Vajrychova M, Koutsilieri S, Sismanoglou DC, Kobrlova T, Prchal L, Svobodova B, Korabecny J, Zarybnicky T, Raisova-Stuchlikova L, Skalova L, Lauschke VM, Kučera R, Soukup O. Novak M, et al. Among authors: kobrlova t. ACS Chem Biol. 2023 Sep 15;18(9):1993-2002. doi: 10.1021/acschembio.3c00219. Epub 2023 Aug 25. ACS Chem Biol. 2023. PMID: 37622522
Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation.
Benek O, Vaskova M, Miskerikova M, Schmidt M, Andrys R, Rotterova A, Skarka A, Hatlapatkova J, Karasova JZ, Medvecky M, Hroch L, Vinklarova L, Fisar Z, Hroudova J, Handl J, Capek J, Rousar T, Kobrlova T, Dolezal R, Soukup O, Aitken L, Gunn-Moore F, Musilek K. Benek O, et al. Among authors: kobrlova t. Eur J Med Chem. 2023 Oct 5;258:115593. doi: 10.1016/j.ejmech.2023.115593. Epub 2023 Jun 24. Eur J Med Chem. 2023. PMID: 37390508
Neurotoxicity evoked by organophosphates and available countermeasures.
Pulkrabkova L, Svobodova B, Konecny J, Kobrlova T, Muckova L, Janousek J, Pejchal J, Korabecny J, Soukup O. Pulkrabkova L, et al. Among authors: kobrlova t. Arch Toxicol. 2023 Jan;97(1):39-72. doi: 10.1007/s00204-022-03397-w. Epub 2022 Nov 6. Arch Toxicol. 2023. PMID: 36335468 Review.
7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties.
Gorecki L, Muthna D, Merdita S, Andrs M, Kucera T, Havelek R, Muckova L, Kobrlova T, Soukup J, Krupa P, Prchal L, Soukup O, Roh J, Rezacova M, Korabecny J. Gorecki L, et al. Among authors: kobrlova t. Eur J Med Chem. 2022 Oct 5;240:114580. doi: 10.1016/j.ejmech.2022.114580. Epub 2022 Jun 30. Eur J Med Chem. 2022. PMID: 35793579
Novel D2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment.
Juza R, Vojtechova I, Stefkova-Mazochova K, Dehaen W, Petrasek T, Prchal L, Kobrlova T, Janousek J, Vlcek P, Mezeiova E, Svozil D, Karasova JZ, Pejchal J, Stark H, Satala G, Bojarski AJ, Kubacka M, Mogilski S, Randakova A, Musilek K, Soukup O, Korabecny J. Juza R, et al. Among authors: kobrlova t. Eur J Med Chem. 2022 Mar 15;232:114193. doi: 10.1016/j.ejmech.2022.114193. Epub 2022 Feb 9. Eur J Med Chem. 2022. PMID: 35176563
Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D2 3,4-dihydroquinolin-2(1H)-one Derivatives Related to Aripiprazole.
Juza R, Stefkova K, Dehaen W, Randakova A, Petrasek T, Vojtechova I, Kobrlova T, Pulkrabkova L, Muckova L, Mecava M, Prchal L, Mezeiova E, Musilek K, Soukup O, Korabecny J. Juza R, et al. Among authors: kobrlova t. Biomolecules. 2021 Aug 24;11(9):1262. doi: 10.3390/biom11091262. Biomolecules. 2021. PMID: 34572475 Free PMC article.
30 results