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Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities.
Oleksak P, Rysanek D, Vancurova M, Vasicova P, Urbancokova A, Novak J, Maurencova D, Kashmel P, Houserova J, Mikyskova R, Novotny O, Reinis M, Juda P, Hons M, Kroupova J, Sedlak D, Sulimenko T, Draber P, Chlubnova M, Nepovimova E, Kuca K, Lisa M, Andrys R, Kobrlova T, Soukup O, Janousek J, Prchal L, Bartek J, Musilek K, Hodny Z. Oleksak P, et al. Among authors: janousek j. ACS Pharmacol Transl Sci. 2024 Aug 12;7(9):2755-2783. doi: 10.1021/acsptsci.4c00190. eCollection 2024 Sep 13. ACS Pharmacol Transl Sci. 2024. PMID: 39296273
Novel D2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment.
Juza R, Vojtechova I, Stefkova-Mazochova K, Dehaen W, Petrasek T, Prchal L, Kobrlova T, Janousek J, Vlcek P, Mezeiova E, Svozil D, Karasova JZ, Pejchal J, Stark H, Satala G, Bojarski AJ, Kubacka M, Mogilski S, Randakova A, Musilek K, Soukup O, Korabecny J. Juza R, et al. Among authors: janousek j. Eur J Med Chem. 2022 Mar 15;232:114193. doi: 10.1016/j.ejmech.2022.114193. Epub 2022 Feb 9. Eur J Med Chem. 2022. PMID: 35176563
Neurotoxicity evoked by organophosphates and available countermeasures.
Pulkrabkova L, Svobodova B, Konecny J, Kobrlova T, Muckova L, Janousek J, Pejchal J, Korabecny J, Soukup O. Pulkrabkova L, et al. Among authors: janousek j. Arch Toxicol. 2023 Jan;97(1):39-72. doi: 10.1007/s00204-022-03397-w. Epub 2022 Nov 6. Arch Toxicol. 2023. PMID: 36335468 Review.
Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease.
Mezeiova E, Prchal L, Hrabinova M, Muckova L, Pulkrabkova L, Soukup O, Misiachna A, Janousek J, Fibigar J, Kucera T, Horak M, Makhaeva GF, Korabecny J. Mezeiova E, et al. Among authors: janousek j. Biomed Pharmacother. 2024 Apr;173:116399. doi: 10.1016/j.biopha.2024.116399. Epub 2024 Mar 15. Biomed Pharmacother. 2024. PMID: 38492439 Free article.
Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies.
Mamun AA, Pidaný F, Hulcová D, Maříková J, Kučera T, Schmidt M, Catapano MC, Hrabinová M, Jun D, Múčková L, Kuneš J, Janoušek J, Andrýs R, Nováková L, Peřinová R, Maafi N, Soukup O, Korábečný J, Cahlíková L. Mamun AA, et al. Among authors: janousek j. Int J Mol Sci. 2021 Aug 2;22(15):8308. doi: 10.3390/ijms22158308. Int J Mol Sci. 2021. PMID: 34361074 Free PMC article.
2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1.
Finger V, Kucera T, Kafkova R, Muckova L, Dolezal R, Kubes J, Novak M, Prchal L, Lakatos L, Andrs M, Hympanova M, Marek J, Kufa M, Spiwok V, Soukup O, Mezeiova E, Janousek J, Nevosadova L, Benkova M, Kitson RRA, Kratky M, Bősze S, Mikusova K, Hartkoorn R, Roh J, Korabecny J. Finger V, et al. Among authors: janousek j. Eur J Med Chem. 2023 Oct 5;258:115611. doi: 10.1016/j.ejmech.2023.115611. Epub 2023 Jul 3. Eur J Med Chem. 2023. PMID: 37421887 Free article.
Carltonine-derived compounds for targeted butyrylcholinesterase inhibition.
Pidany F, Kroustkova J, Jenco J, Breiterova KH, Muckova L, Novakova L, Kunes J, Fibigar J, Kucera T, Novak M, Sorf A, Hrabinova M, Pulkrabkova L, Janousek J, Soukup O, Jun D, Korabecny J, Cahlikova L. Pidany F, et al. Among authors: janousek j. RSC Med Chem. 2024 Mar 22;15(5):1601-1625. doi: 10.1039/d4md00060a. eCollection 2024 May 22. RSC Med Chem. 2024. PMID: 38784455 Free PMC article.
Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study.
Maafi N, Pidaný F, Maříková J, Korábečný J, Hulcová D, Kučera T, Schmidt M, Shammari LA, Špulák M, Carmen Catapano M, Mecava M, Prchal L, Kuneš J, Janoušek J, Kohelová E, Jenčo J, Nováková L, Cahlíková L. Maafi N, et al. Among authors: janousek j. Bioorg Med Chem Lett. 2021 Nov 1;51:128374. doi: 10.1016/j.bmcl.2021.128374. Epub 2021 Sep 21. Bioorg Med Chem Lett. 2021. PMID: 34555506
230 results