Nepali K - Search Results

1

Scaffold hopping approaches for dual-target antitumor drug discovery: opportunities and challenges.

Mishra A, Thakur A, Sharma R, Onuku R, Kaur C, Liou JP, Hsu SP, Nepali K. Mishra A, et al. Among authors: nepali k. Expert Opin Drug Discov. 2024 Nov;19(11):1355-1381. doi: 10.1080/17460441.2024.2409674. Epub 2024 Oct 17. Expert Opin Drug Discov. 2024. PMID: 39420580 Review.

2

Syntheses of LSD1/HDAC Inhibitors with Demonstrated Efficacy against Colorectal Cancer: In Vitro and In Vivo Studies Including Patient-Derived Organoids.

Chou PY, Lai MJ, Tsai KK, Cheng LH, Wu YW, Chen MC, Pan SL, Ho HO, Nepali K, Liou JP. Chou PY, et al. Among authors: nepali k. J Med Chem. 2024 Oct 10;67(19):17207-17225. doi: 10.1021/acs.jmedchem.4c01098. Epub 2024 Sep 25. J Med Chem. 2024. PMID: 39320444 Free PMC article.

3

Rationally designed febuxostat-based hydroxamic acid and its pH-Responsive nanoformulation elicits anti-tumor activity.

Ritika, Liao ZY, Chen PY, Rao NV, Mathew J, Sharma R, Grewal AS, Singh G, Mehan S, Liou JP, Pan CH, Nepali K. Ritika, et al. Among authors: nepali k. Eur J Med Chem. 2024 Dec 5;279:116866. doi: 10.1016/j.ejmech.2024.116866. Epub 2024 Sep 10. Eur J Med Chem. 2024. PMID: 39293244

4

Spleen tyrosine kinase (SYK): an emerging target for the assemblage of small molecule antitumor agents.

Kaur C, Thakur A, Liou KC, Rao NV, Nepali K. Kaur C, et al. Among authors: nepali k. Expert Opin Investig Drugs. 2024 Sep;33(9):897-914. doi: 10.1080/13543784.2024.2388559. Epub 2024 Aug 11. Expert Opin Investig Drugs. 2024. PMID: 39096234 Review.

5

Leveraging a rationally designed veliparib-based anilide eliciting anti-leukemic effects for the design of pH-responsive polymer nanoformulation.

Thakur A, Chu YH, Rao NV, Mathew J, Grewal AS, Prabakaran P, Guru S, Liou JP, Pan CH, Nepali K. Thakur A, et al. Among authors: nepali k. Eur J Med Chem. 2024 Jul 5;273:116507. doi: 10.1016/j.ejmech.2024.116507. Epub 2024 May 17. Eur J Med Chem. 2024. PMID: 38776806

6

Recent advances and future directions on small molecule VEGFR inhibitors in oncological conditions.

Thakur A, Rana M, Mishra A, Kaur C, Pan CH, Nepali K. Thakur A, et al. Among authors: nepali k. Eur J Med Chem. 2024 Jun 5;272:116472. doi: 10.1016/j.ejmech.2024.116472. Epub 2024 May 6. Eur J Med Chem. 2024. PMID: 38728867 Review.

7

Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress.

Sharma R, Chiang YH, Chen HC, Lin HY, Yang WB, Nepali K, Lai MJ, Chen KY, Liou JP, Hsu TI. Sharma R, et al. Among authors: nepali k. Cancer Lett. 2024 Apr 1;586:216666. doi: 10.1016/j.canlet.2024.216666. Epub 2024 Feb 2. Cancer Lett. 2024. PMID: 38311053

8

First-in-Class Dual EZH2-HSP90 Inhibitor Eliciting Striking Antiglioblastoma Activity In Vitro and In Vivo.

Sharma S, Wang SA, Yang WB, Lin HY, Lai MJ, Chen HC, Kao TY, Hsu FL, Nepali K, Hsu TI, Liou JP. Sharma S, et al. Among authors: nepali k. J Med Chem. 2024 Feb 22;67(4):2963-2985. doi: 10.1021/acs.jmedchem.3c02053. Epub 2024 Jan 29. J Med Chem. 2024. PMID: 38285511 Free PMC article.

9

N-Heterocycle based Degraders (PROTACs) Manifesting Anticancer Efficacy: Recent Advances.

Banerjee S, Sharma S, Thakur A, Sachdeva R, Sharma R, Nepali K, Liou JP. Banerjee S, et al. Among authors: nepali k. Curr Drug Targets. 2023;24(15):1184-1208. doi: 10.2174/0113894501273969231102095615. Curr Drug Targets. 2023. PMID: 37946353 Review.

10

Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer.

Sharma S, Chandra K, Naik A, Sharma A, Sharma R, Thakur A, Grewal AS, Dhingra AK, Banerjee A, Liou JP, Guru SK, Nepali K. Sharma S, et al. Among authors: nepali k. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2276665. doi: 10.1080/14756366.2023.2276665. Epub 2023 Nov 2. J Enzyme Inhib Med Chem. 2023. PMID: 37919954 Free PMC article.

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