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Page 1
SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years.
Rowntree LC, Audsley J, Allen LF, McQuilten HA, Hagen RR, Chaurasia P, Petersen J, Littler DR, Tan HX, Murdiyarso L, Habel JR, Foo IJH, Zhang W, Ten Berge ERV, Ganesh H, Kaewpreedee P, Lee KWK, Cheng SMS, Kwok JSY, Jayasinghe D, Gras S, Juno JA, Wheatley AK, Kent SJ, Rossjohn J, Cheng AC, Kotsimbos TC, Trubiano JA, Holmes NE, Pang Chan KK, Hui DSC, Peiris M, Poon LLM, Lewin SR, Doherty PC, Thevarajan I, Valkenburg SA, Kedzierska K, Nguyen THO. Rowntree LC, et al. Among authors: allen lf. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2411428121. doi: 10.1073/pnas.2411428121. Epub 2024 Sep 16. Proc Natl Acad Sci U S A. 2024. PMID: 39284068 Free PMC article.
CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity.
Nguyen THO, Rowntree LC, Petersen J, Chua BY, Hensen L, Kedzierski L, van de Sandt CE, Chaurasia P, Tan HX, Habel JR, Zhang W, Allen LF, Earnest L, Mak KY, Juno JA, Wragg K, Mordant FL, Amanat F, Krammer F, Mifsud NA, Doolan DL, Flanagan KL, Sonda S, Kaur J, Wakim LM, Westall GP, James F, Mouhtouris E, Gordon CL, Holmes NE, Smibert OC, Trubiano JA, Cheng AC, Harcourt P, Clifton P, Crawford JC, Thomas PG, Wheatley AK, Kent SJ, Rossjohn J, Torresi J, Kedzierska K. Nguyen THO, et al. Among authors: allen lf. Immunity. 2021 May 11;54(5):1066-1082.e5. doi: 10.1016/j.immuni.2021.04.009. Epub 2021 Apr 15. Immunity. 2021. PMID: 33951417 Free PMC article.
SARS-CoV-2-specific T cell memory with common TCRαβ motifs is established in unvaccinated children who seroconvert after infection.
Rowntree LC, Nguyen THO, Kedzierski L, Neeland MR, Petersen J, Crawford JC, Allen LF, Clemens EB, Chua B, McQuilten HA, Minervina AA, Pogorelyy MV, Chaurasia P, Tan HX, Wheatley AK, Jia X, Amanat F, Krammer F, Allen EK, Sonda S, Flanagan KL, Jumarang J, Pannaraj PS, Licciardi PV, Kent SJ, Bond KA, Williamson DA, Rossjohn J, Thomas PG, Tosif S, Crawford NW, van de Sandt CE, Kedzierska K. Rowntree LC, et al. Among authors: allen lf, allen ek. Immunity. 2022 Jul 12;55(7):1299-1315.e4. doi: 10.1016/j.immuni.2022.06.003. Epub 2022 Jun 8. Immunity. 2022. PMID: 35750048 Free PMC article.
Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals.
von Borstel A, Nguyen TH, Rowntree LC, Ashhurst TM, Allen LF, Howson LJ, Holmes NE, Smibert OC, Trubiano JA, Gordon CL, Cheng AC, Kent SJ, Rossjohn J, Kedzierska K, Davey MS. von Borstel A, et al. Among authors: allen lf. Immunol Cell Biol. 2023 Apr;101(4):321-332. doi: 10.1111/imcb.12623. Epub 2023 Feb 19. Immunol Cell Biol. 2023. PMID: 36698330
Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells.
Nguyen THO, Rowntree LC, Allen LF, Chua BY, Kedzierski L, Lim C, Lasica M, Tennakoon GS, Saunders NR, Crane M, Chee L, Seymour JF, Anderson MA, Whitechurch A, Clemens EB, Zhang W, Chang SY, Habel JR, Jia X, McQuilten HA, Minervina AA, Pogorelyy MV, Chaurasia P, Petersen J, Menon T, Hensen L, Neil JA, Mordant FL, Tan HX, Cabug AF, Wheatley AK, Kent SJ, Subbarao K, Karapanagiotidis T, Huang H, Vo LK, Cain NL, Nicholson S, Krammer F, Gibney G, James F, Trevillyan JM, Trubiano JA, Mitchell J, Christensen B, Bond KA, Williamson DA, Rossjohn J, Crawford JC, Thomas PG, Thursky KA, Slavin MA, Tam CS, Teh BW, Kedzierska K. Nguyen THO, et al. Among authors: allen lf. Cell Rep Med. 2023 Apr 18;4(4):101017. doi: 10.1016/j.xcrm.2023.101017. Epub 2023 Mar 27. Cell Rep Med. 2023. PMID: 37030296 Free PMC article.
Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations.
Habel JR, Chua BY, Kedzierski L, Selva KJ, Damelang T, Haycroft ER, Nguyen TH, Koay HF, Nicholson S, McQuilten HA, Jia X, Allen LF, Hensen L, Zhang W, van de Sandt CE, Neil JA, Pragastis K, Lau JS, Jumarang J, Allen EK, Amanant F, Krammer F, Wragg KM, Juno JA, Wheatley AK, Tan HX, Pell G, Walker S, Audsley J, Reynaldi A, Thevarajan I, Denholm JT, Subbarao K, Davenport MP, Hogarth PM, Godfrey DI, Cheng AC, Tong SY, Bond K, Williamson DA, McMahon JH, Thomas PG, Pannaraj PS, James F, Holmes NE, Smibert OC, Trubiano JA, Gordon CL, Chung AW, Whitehead CL, Kent SJ, Lappas M, Rowntree LC, Kedzierska K. Habel JR, et al. Among authors: allen lf. JCI Insight. 2023 Apr 10;8(7):e167157. doi: 10.1172/jci.insight.167157. JCI Insight. 2023. PMID: 37036008 Free PMC article.
Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities.
Zhang W, Kedzierski L, Chua BY, Mayo M, Lonzi C, Rigas V, Middleton BF, McQuilten HA, Rowntree LC, Allen LF, Purcell RA, Tan HX, Petersen J, Chaurasia P, Mordant F, Pogorelyy MV, Minervina AA, Crawford JC, Perkins GB, Zhang E, Gras S, Clemens EB, Juno JA, Audsley J, Khoury DS, Holmes NE, Thevarajan I, Subbarao K, Krammer F, Cheng AC, Davenport MP, Grubor-Bauk B, Coates PT, Christensen B, Thomas PG, Wheatley AK, Kent SJ, Rossjohn J, Chung AW, Boffa J, Miller A, Lynar S, Nelson J, Nguyen THO, Davies J, Kedzierska K. Zhang W, et al. Among authors: allen lf. Nat Immunol. 2023 Jun;24(6):966-978. doi: 10.1038/s41590-023-01508-y. Epub 2023 May 29. Nat Immunol. 2023. PMID: 37248417 Free PMC article.
Broad spectrum SARS-CoV-2-specific immunity in hospitalized First Nations peoples recovering from COVID-19.
Zhang W, Clemens EB, Kedzierski L, Chua BY, Mayo M, Lonzi C, Hinchcliff A, Rigas V, Middleton BF, Binks P, Rowntree LC, Allen LF, Tan HX, Petersen J, Chaurasia P, Krammer F, Wheatley AK, Kent SJ, Rossjohn J, Miller A, Lynar S, Nelson J, Nguyen TH, Davies J, Kedzierska K. Zhang W, et al. Among authors: allen lf. Immunol Cell Biol. 2023 Nov-Dec;101(10):964-974. doi: 10.1111/imcb.12691. Epub 2023 Sep 19. Immunol Cell Biol. 2023. PMID: 37725525 Free PMC article.
CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age.
Menon T, Illing PT, Chaurasia P, McQuilten HA, Shepherd C, Rowntree LC, Petersen J, Littler DR, Khuu G, Huang Z, Allen LF, Rockman S, Crowe J, Flanagan KL, Wakim LM, Nguyen THO, Mifsud NA, Rossjohn J, Purcell AW, van de Sandt CE, Kedzierska K. Menon T, et al. Among authors: allen lf. Nat Commun. 2024 Apr 29;15(1):3387. doi: 10.1038/s41467-024-47576-y. Nat Commun. 2024. PMID: 38684663 Free PMC article.
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity.
Zhang W, Chua BY, Selva KJ, Kedzierski L, Ashhurst TM, Haycroft ER, Shoffner-Beck SK, Hensen L, Boyd DF, James F, Mouhtouris E, Kwong JC, Chua KYL, Drewett G, Copaescu A, Dobson JE, Rowntree LC, Habel JR, Allen LF, Koay HF, Neil JA, Gartner MJ, Lee CY, Andersson P, Khan SF, Blakeway L, Wisniewski J, McMahon JH, Vine EE, Cunningham AL, Audsley J, Thevarajan I, Seemann T, Sherry NL, Amanat F, Krammer F, Londrigan SL, Wakim LM, King NJC, Godfrey DI, Mackay LK, Thomas PG, Nicholson S, Arnold KB, Chung AW, Holmes NE, Smibert OC, Trubiano JA, Gordon CL, Nguyen THO, Kedzierska K. Zhang W, et al. Among authors: allen lf. Nat Commun. 2022 May 19;13(1):2774. doi: 10.1038/s41467-022-30088-y. Nat Commun. 2022. PMID: 35589689 Free PMC article.
55 results