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Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function.
Miller LVC, Papa G, Vaysburd M, Cheng S, Sweeney PW, Smith A, Franco C, Katsinelos T, Huang M, Sanford SAI, Benn J, Farnsworth J, Higginson K, Joyner H, McEwan WA, James LC. Miller LVC, et al. Among authors: vaysburd m. Cell. 2024 Oct 17;187(21):5967-5980.e17. doi: 10.1016/j.cell.2024.08.024. Epub 2024 Sep 13. Cell. 2024. PMID: 39276772 Free PMC article.
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Tuck BJ, Miller LVC, Katsinelos T, Smith AE, Wilson EL, Keeling S, Cheng S, Vaysburd MJ, Knox C, Tredgett L, Metzakopian E, James LC, McEwan WA. Tuck BJ, et al. Among authors: vaysburd mj. Cell Rep. 2022 May 3;39(5):110776. doi: 10.1016/j.celrep.2022.110776. Cell Rep. 2022. PMID: 35508140 Free PMC article.
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.
McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC. McEwan WA, et al. Among authors: vaysburd m. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):574-579. doi: 10.1073/pnas.1607215114. Epub 2017 Jan 3. Proc Natl Acad Sci U S A. 2017. PMID: 28049840 Free PMC article.
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Mukadam AS, Miller LVC, Smith AE, Vaysburd M, Sakya SA, Sanford S, Keeling S, Tuck BJ, Katsinelos T, Green C, Skov L, Kaalund SS, Foss S, Mayes K, O'Connell K, Wing M, Knox C, Banbury J, Avezov E, Rowe JB, Goedert M, Andersen JT, James LC, McEwan WA. Mukadam AS, et al. Among authors: vaysburd m. Science. 2023 Mar 31;379(6639):1336-1341. doi: 10.1126/science.abn1366. Epub 2023 Mar 30. Science. 2023. PMID: 36996217 Free PMC article.
Aggregate-selective removal of pathological tau by clustering-activated degraders.
Benn J, Cheng S, Keeling S, Smith AE, Vaysburd MJ, Böken D, Miller LVC, Katsinelos T, Franco C, Dupré E, Danis C, Landrieu I, Buée L, Klenerman D, James LC, McEwan WA. Benn J, et al. Among authors: vaysburd mj. Science. 2024 Aug 30;385(6712):1009-1016. doi: 10.1126/science.adp5186. Epub 2024 Aug 29. Science. 2024. PMID: 39208111 Free PMC article.
Complement C4 Prevents Viral Infection through Capsid Inactivation.
Bottermann M, Foss S, Caddy SL, Clift D, van Tienen LM, Vaysburd M, Cruickshank J, O'Connell K, Clark J, Mayes K, Higginson K, Lode HE, McAdam MB, Sandlie I, Andersen JT, James LC. Bottermann M, et al. Among authors: vaysburd m. Cell Host Microbe. 2019 Apr 10;25(4):617-629.e7. doi: 10.1016/j.chom.2019.02.016. Epub 2019 Mar 26. Cell Host Microbe. 2019. PMID: 30926239 Free PMC article.
33 results