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Page 1
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function.
Miller LVC, Papa G, Vaysburd M, Cheng S, Sweeney PW, Smith A, Franco C, Katsinelos T, Huang M, Sanford SAI, Benn J, Farnsworth J, Higginson K, Joyner H, McEwan WA, James LC. Miller LVC, et al. Among authors: katsinelos t. Cell. 2024 Oct 17;187(21):5967-5980.e17. doi: 10.1016/j.cell.2024.08.024. Epub 2024 Sep 13. Cell. 2024. PMID: 39276772 Free PMC article.
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.
Dimou E, Katsinelos T, Meisl G, Tuck BJ, Keeling S, Smith AE, Hidari E, Lam JYL, Burke M, Lövestam S, Ranasinghe RT, McEwan WA, Klenerman D. Dimou E, et al. Among authors: katsinelos t. Cell Rep. 2023 Jul 25;42(7):112725. doi: 10.1016/j.celrep.2023.112725. Epub 2023 Jul 1. Cell Rep. 2023. PMID: 37393617 Free PMC article.
Tau seeds from Alzheimer's disease brains trigger tau spread in macaques while oligomeric-Aβ mediates pathology maturation.
Darricau M, Dou C, Kinet R, Zhu T, Zhou L, Li X, Bedel A, Claverol S, Tokarski C, Katsinelos T, McEwan WA, Zhang L, Gao R, Bourdenx M, Dehay B, Qin C, Bezard E, Planche V. Darricau M, et al. Among authors: katsinelos t. Alzheimers Dement. 2024 Mar;20(3):1894-1912. doi: 10.1002/alz.13604. Epub 2023 Dec 26. Alzheimers Dement. 2024. PMID: 38148705 Free PMC article.
Drosophila appear resistant to trans-synaptic tau propagation.
Catterson JH, Mouofo EN, López De Toledo Soler I, Lean G, Dlamini S, Liddell P, Voong G, Katsinelos T, Wang YC, Schoovaerts N, Verstreken P, Spires-Jones TL, Durrant CS. Catterson JH, et al. Among authors: katsinelos t. Brain Commun. 2024 Aug 8;6(4):fcae256. doi: 10.1093/braincomms/fcae256. eCollection 2024. Brain Commun. 2024. PMID: 39130515 Free PMC article.
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells.
Ghetti B, Schweighauser M, Jacobsen MH, Gray D, Bacioglu M, Murzin AG, Glazier BS, Katsinelos T, Vidal R, Newell KL, Gao S, Garringer HJ, Spillantini MG, Scheres SHW, Goedert M. Ghetti B, et al. Among authors: katsinelos t. Acta Neuropathol. 2024 Nov 6;148(1):60. doi: 10.1007/s00401-024-02807-w. Acta Neuropathol. 2024. PMID: 39503754 Free PMC article.
Correction: Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems.
Bacioglu M, Bacioglu M, Gray D, Lövestam S, Katsinelos T, Quaegebeur A, van Swieten J, Jaunmuktane Z, Davies SW, Scheres SHW, Goedert M, Ghetti B, Spillantini MG. Bacioglu M, et al. Among authors: katsinelos t. Acta Neuropathol Commun. 2024 Aug 14;12(1):131. doi: 10.1186/s40478-024-01842-8. Acta Neuropathol Commun. 2024. PMID: 39138552 Free PMC article. No abstract available.
Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems.
Bacioglu M, Schweighauser M, Gray D, Lövestam S, Katsinelos T, Quaegebeur A, van Swieten J, Jaunmuktane Z, Davies SW, Scheres SHW, Goedert M, Ghetti B, Spillantini MG. Bacioglu M, et al. Among authors: katsinelos t. Acta Neuropathol Commun. 2024 Jun 17;12(1):99. doi: 10.1186/s40478-024-01813-z. Acta Neuropathol Commun. 2024. PMID: 38886865 Free PMC article.
Aggregate-selective removal of pathological tau by clustering-activated degraders.
Benn J, Cheng S, Keeling S, Smith AE, Vaysburd MJ, Böken D, Miller LVC, Katsinelos T, Franco C, Dupré E, Danis C, Landrieu I, Buée L, Klenerman D, James LC, McEwan WA. Benn J, et al. Among authors: katsinelos t. Science. 2024 Aug 30;385(6712):1009-1016. doi: 10.1126/science.adp5186. Epub 2024 Aug 29. Science. 2024. PMID: 39208111 Free PMC article.
49 results