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IFN-γ Drives Human Monocyte Differentiation into Highly Proinflammatory Macrophages That Resemble a Phenotype Relevant to Psoriasis.
Luque-Martin R, Angell DC, Kalxdorf M, Bernard S, Thompson W, Eberl HC, Ashby C, Freudenberg J, Sharp C, Van den Bossche J, de Jonge WJ, Rioja I, Prinjha RK, Neele AE, de Winther MPJ, Mander PK. Luque-Martin R, et al. Among authors: de jonge wj, de winther mpj. J Immunol. 2021 Jul 15;207(2):555-568. doi: 10.4049/jimmunol.2001310. Epub 2021 Jul 7. J Immunol. 2021. PMID: 34233910
DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.
Willemsen L, Prange KHM, Neele AE, van Roomen CPAA, Gijbels M, Griffith GR, Toom MD, Beckers L, Siebeler R, Spann NJ, Chen HJ, Bosmans LA, Gorbatenko A, van Wouw S, Zelcer N, Jacobs H, van Leeuwen F, de Winther MPJ. Willemsen L, et al. Among authors: de winther mpj. Cell Rep. 2022 Nov 22;41(8):111703. doi: 10.1016/j.celrep.2022.111703. Cell Rep. 2022. PMID: 36417856 Free article.
Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.
Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MC, Ahmed M, Hoeksema MA, de Vos AF, de Winther MP. Van den Bossche J, et al. Cell Rep. 2016 Oct 11;17(3):684-696. doi: 10.1016/j.celrep.2016.09.008. Cell Rep. 2016. PMID: 27732846 Free article.
Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis.
Luque-Martin R, Van den Bossche J, Furze RC, Neele AE, van der Velden S, Gijbels MJJ, van Roomen CPPA, Bernard SG, de Jonge WJ, Rioja I, Prinjha RK, Lewis HD, Mander PK, de Winther MPJ. Luque-Martin R, et al. Among authors: de jonge wj, de winther mpj. Front Pharmacol. 2019 Oct 29;10:1242. doi: 10.3389/fphar.2019.01242. eCollection 2019. Front Pharmacol. 2019. PMID: 31736752 Free PMC article.
Type-I interferons in atherosclerosis.
Chen HJ, Tas SW, de Winther MPJ. Chen HJ, et al. Among authors: de winther mpj. J Exp Med. 2020 Jan 6;217(1):e20190459. doi: 10.1084/jem.20190459. J Exp Med. 2020. PMID: 31821440 Free PMC article. Review.
Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss.
Willemsen L, Neele AE, van der Velden S, Prange KHM, den Toom M, van Roomen CPAA, Reiche ME, Griffith GR, Gijbels MJJ, Lutgens E, de Winther MPJ. Willemsen L, et al. Among authors: de winther mpj. BMJ Open Diabetes Res Care. 2019 Nov 2;7(1):e000751. doi: 10.1136/bmjdrc-2019-000751. eCollection 2019. BMJ Open Diabetes Res Care. 2019. PMID: 31798899 Free PMC article.
190 results