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In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer.
Quintela M, James DW, Garcia J, Edwards K, Margarit L, Das N, Lutchman-Singh K, Beynon AL, Rioja I, Prinjha RK, Harker NR, Gonzalez D, Steven Conlan R, Francis LW. Quintela M, et al. Among authors: prinjha rk. Br J Cancer. 2023 Jul;129(1):163-174. doi: 10.1038/s41416-023-02274-2. Epub 2023 Apr 29. Br J Cancer. 2023. PMID: 37120667 Free PMC article.
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.
Williams TD, Michalak EM, Carey KT, Lam EYN, Anderson A, Griesbach E, Chan YC, Papasaikas P, Tan VWT, Ngo L, MacPherson L, Gilan O, Rucinski A, Rutkowska-Klute A, Zinn N, Grandi P, Bantscheff M, Prinjha RK, Dawson SJ, Chao JA, Wickramasinghe VO, Dawson MA. Williams TD, et al. Among authors: prinjha rk. Mol Cell. 2025 Jan 2;85(1):117-131.e7. doi: 10.1016/j.molcel.2024.12.008. Mol Cell. 2025. PMID: 39753105
Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation.
Shah V, Giotopoulos G, Osaki H, Meyerhöfer M, Meduri E, Gallego-Crespo A, Behrendt MA, Saura-Pañella M, Tarkar A, Schubert B, Yun H, Horton SJ, Agrawal-Singh S Dr, Hähnel PS, Basheer F, Lugo D, Eleftheriadou I, Barbash O, Dhar A, Kühn M, Guezguez B, Theobald M, Kindler T, Gallipoli P, Yeh PS, Dawson MA, Prinjha RK, Huntly BJ, Sasca D. Shah V, et al. Among authors: prinjha rk. Blood. 2024 Dec 9:blood.2022019306. doi: 10.1182/blood.2022019306. Online ahead of print. Blood. 2024. PMID: 39651888
Novel insights into the dynamic function of PRC2 in innate immunity.
Kempkes RWM, Prinjha RK, de Winther MPJ, Neele AE. Kempkes RWM, et al. Among authors: prinjha rk. Trends Immunol. 2024 Dec;45(12):1015-1030. doi: 10.1016/j.it.2024.10.003. Epub 2024 Nov 27. Trends Immunol. 2024. PMID: 39603889 Free article. Review.
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787.
Hirst DJ, Bamborough P, Al-Mahdi N, Angell DC, Barnett HA, Baxter A, Bit RA, Brown JA, Chung CW, Craggs PD, Davis RP, Demont EH, Ferrie A, Gordon LJ, Harada I, Ho TCT, Holyer ID, Hooper-Greenhill E, Jones KL, Lindon MJ, Lovatt C, Lugo D, Maller C, McGonagle G, Messenger C, Mitchell DJ, Pascoe DD, Patel VK, Patten C, Poole DL, Shah RR, Rioja I, Stafford KAJ, Tape D, Taylor S, Theodoulou NH, Tomlinson L, Wall ID, Wellaway CR, White G, Prinjha RK, Humphreys PG. Hirst DJ, et al. Among authors: prinjha rk. J Med Chem. 2024 Jun 27;67(12):10464-10489. doi: 10.1021/acs.jmedchem.4c00959. Epub 2024 Jun 12. J Med Chem. 2024. PMID: 38866424
Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe.
Bradley E, Fusani L, Chung CW, Craggs PD, Demont EH, Humphreys PG, Mitchell DJ, Phillipou A, Rioja I, Shah RR, Wellaway CR, Prinjha RK, Palmer DS, Kerr WJ, Reid M, Wall ID, Cookson R. Bradley E, et al. Among authors: prinjha rk. J Med Chem. 2023 Dec 14;66(23):15728-15749. doi: 10.1021/acs.jmedchem.3c00906. Epub 2023 Nov 15. J Med Chem. 2023. PMID: 37967462 Free PMC article.
145 results