Wellendorph P - Search Results

1

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity.

Narayanan D, Larsen ASG, Gauger SJ, Adafia R, Hammershøi RB, Hamborg L, Bruus-Jensen J, Griem-Krey N, Gee CL, Frølund B, Stratton MM, Kuriyan J, Kastrup JS, Langkilde AE, Wellendorph P, Solbak SMØ. Narayanan D, et al. Among authors: wellendorph p. Protein Sci. 2024 Oct;33(10):e5152. doi: 10.1002/pro.5152. Protein Sci. 2024. PMID: 39275999 Free PMC article.

2

Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.

Wellendorph P, Høg S, Greenwood JR, de Lichtenberg A, Nielsen B, Frølund B, Brehm L, Clausen RP, Bräuner-Osborne H. Wellendorph P, et al. J Pharmacol Exp Ther. 2005 Oct;315(1):346-51. doi: 10.1124/jpet.105.090472. Epub 2005 Jul 12. J Pharmacol Exp Ther. 2005. PMID: 16014570

3

Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.

Høg S, Wellendorph P, Nielsen B, Frydenvang K, Dahl IF, Bräuner-Osborne H, Brehm L, Frølund B, Clausen RP. Høg S, et al. Among authors: wellendorph p. J Med Chem. 2008 Dec 25;51(24):8088-95. doi: 10.1021/jm801112u. J Med Chem. 2008. PMID: 19053823

4

Novel radioiodinated {gamma}-hydroxybutyric acid analogues for radiolabeling and Photolinking of high-affinity {gamma}-hydroxybutyric acid binding sites.

Wellendorph P, Høg S, Sabbatini P, Pedersen MH, Martiny L, Knudsen GM, Frølund B, Clausen RP, Bräuner-Osborne H. Wellendorph P, et al. J Pharmacol Exp Ther. 2010 Nov;335(2):458-64. doi: 10.1124/jpet.110.170670. Epub 2010 Aug 9. J Pharmacol Exp Ther. 2010. PMID: 20696866

5

Design, synthesis, and in vitro pharmacology of new radiolabeled gamma-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity gamma-hydroxybutyric acid binding sites.

Sabbatini P, Wellendorph P, Høg S, Pedersen MH, Bräuner-Osborne H, Martiny L, Frølund B, Clausen RP. Sabbatini P, et al. Among authors: wellendorph p. J Med Chem. 2010 Sep 9;53(17):6506-10. doi: 10.1021/jm1006325. J Med Chem. 2010. PMID: 20715819

6

Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.

Jensen AA, Plath N, Pedersen MH, Isberg V, Krall J, Wellendorph P, Stensbøl TB, Gloriam DE, Krogsgaard-Larsen P, Frølund B. Jensen AA, et al. Among authors: wellendorph p. J Med Chem. 2013 Feb 14;56(3):1211-27. doi: 10.1021/jm301656h. Epub 2013 Jan 17. J Med Chem. 2013. PMID: 23301527

7

New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites.

Vogensen SB, Marek A, Bay T, Wellendorph P, Kehler J, Bundgaard C, Frølund B, Pedersen MH, Clausen RP. Vogensen SB, et al. Among authors: wellendorph p. J Med Chem. 2013 Oct 24;56(20):8201-5. doi: 10.1021/jm4011719. Epub 2013 Oct 4. J Med Chem. 2013. PMID: 24053696 Free PMC article.

8

Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).

Al-Khawaja A, Petersen JG, Damgaard M, Jensen MH, Vogensen SB, Lie ME, Kragholm B, Bräuner-Osborne H, Clausen RP, Frølund B, Wellendorph P. Al-Khawaja A, et al. Among authors: wellendorph p. Neurochem Res. 2014 Oct;39(10):1988-96. doi: 10.1007/s11064-014-1336-9. Epub 2014 May 23. Neurochem Res. 2014. PMID: 24852577

9

Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin.

Eghorn LF, Hoestgaard-Jensen K, Kongstad KT, Bay T, Higgins D, Frølund B, Wellendorph P. Eghorn LF, et al. Among authors: wellendorph p. Eur J Pharmacol. 2014 Oct 5;740:570-7. doi: 10.1016/j.ejphar.2014.06.028. Epub 2014 Jun 25. Eur J Pharmacol. 2014. PMID: 24973695

10

In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1.

Thiesen L, Kehler J, Clausen RP, Frølund B, Bundgaard C, Wellendorph P. Thiesen L, et al. Among authors: wellendorph p. J Pharmacol Exp Ther. 2015 Aug;354(2):166-74. doi: 10.1124/jpet.115.224543. Epub 2015 May 18. J Pharmacol Exp Ther. 2015. PMID: 25986445

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