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IL-4 drives exhaustion of CD8+ CART cells.
Stewart CM, Siegler EL, Sakemura RL, Cox MJ, Huynh T, Kimball B, Mai L, Can I, Manriquez Roman C, Yun K, Sirpilla O, Girsch JH, Ogbodo E, Mohammed Ismail W, Gaspar-Maia A, Budka J, Kim J, Scholler N, Mattie M, Filosto S, Kenderian SS. Stewart CM, et al. Among authors: siegler el. Nat Commun. 2024 Sep 12;15(1):7921. doi: 10.1038/s41467-024-51978-3. Nat Commun. 2024. PMID: 39266501 Free PMC article.
CRISPR Takes the Front Seat in CART-Cell Development.
Manriquez-Roman C, Siegler EL, Kenderian SS. Manriquez-Roman C, et al. Among authors: siegler el. BioDrugs. 2021 Mar;35(2):113-124. doi: 10.1007/s40259-021-00473-y. Epub 2021 Feb 27. BioDrugs. 2021. PMID: 33638865 Review.
Who wins the combat, CAR or TCR?
Yun K, Siegler EL, Kenderian SS. Yun K, et al. Among authors: siegler el. Leukemia. 2023 Oct;37(10):1953-1962. doi: 10.1038/s41375-023-01976-z. Epub 2023 Aug 25. Leukemia. 2023. PMID: 37626090 Review.
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression.
Sirpilla O, Sakemura RL, Hefazi M, Huynh TN, Can I, Girsch JH, Tapper EE, Cox MJ, Schick KJ, Manriquez-Roman C, Yun K, Stewart CM, Ogbodo EJ, Kimball BL, Mai LK, Gutierrez-Ruiz OL, Rodriguez ML, Gluscevic M, Larson DP, Abel AM, Wierson WA, Olivier G, Siegler EL, Kenderian SS. Sirpilla O, et al. Among authors: siegler el. Nat Biomed Eng. 2024 Apr;8(4):443-460. doi: 10.1038/s41551-024-01195-6. Epub 2024 Apr 1. Nat Biomed Eng. 2024. PMID: 38561490
Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia.
Cox MJ, Lucien F, Sakemura R, Boysen JC, Kim Y, Horvei P, Manriquez Roman C, Hansen MJ, Tapper EE, Siegler EL, Forsman C, Crotts SB, Schick KJ, Hefazi M, Ruff MW, Can I, Adada M, Bezerra E, Kankeu Fonkoua LA, Nevala WK, Braggio E, Ding W, Parikh SA, Kay NE, Kenderian SS. Cox MJ, et al. Among authors: siegler el. Mol Ther. 2021 Apr 7;29(4):1529-1540. doi: 10.1016/j.ymthe.2020.12.033. Epub 2021 Jan 1. Mol Ther. 2021. PMID: 33388419 Free PMC article.
100 results