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Further Probing the Properties of a Unique Sponge-derived Alkaloid Through the Isolation of a New (-)-(5E)-(8R)-(14Z)-Mycothiazole Analogue.
Gerke JA, Odron SF, Kim J, Dutta N, Clarke JG, Media J, Coppage DA, Oorloff M, Alcala A, Garcia G, Kang MEF, Gerke CL, Peterson JC, Morris JD, Higuchi-Sanabria R, Valeriote FA, Crews P, Johnson TA. Gerke JA, et al. Among authors: higuchi sanabria r. J Nat Prod. 2024 Oct 25;87(10):2523-2529. doi: 10.1021/acs.jnatprod.4c00691. Epub 2024 Sep 30. J Nat Prod. 2024. PMID: 39348562
Growth on stiffer substrates impacts animal health and longevity in C. elegans.
Oorloff M, Hruby A, Averbukh M, Alcala A, Dutta N, Minor C, Castro Torres T, Moaddeli D, Vega M, Kim J, Bong A, Coakley AJ, Hicks D, Wang J, Wang T, Hoang S, Tharp KM, Garcia G, Higuchi-Sanabria R. Oorloff M, et al. Among authors: higuchi sanabria r. PLoS One. 2024 Sep 12;19(9):e0302673. doi: 10.1371/journal.pone.0302673. eCollection 2024. PLoS One. 2024. PMID: 39264947 Free PMC article.
The extracellular matrix integrates mitochondrial homeostasis.
Zhang H, Tsui CK, Garcia G, Joe LK, Wu H, Maruichi A, Fan W, Pandovski S, Yoon PH, Webster BM, Durieux J, Frankino PA, Higuchi-Sanabria R, Dillin A. Zhang H, et al. Among authors: higuchi sanabria r. Cell. 2024 Aug 8;187(16):4289-4304.e26. doi: 10.1016/j.cell.2024.05.057. Epub 2024 Jun 27. Cell. 2024. PMID: 38942015
Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.
Coakley AJ, Hruby A, Wang J, Bong A, Nair T, Ramos CM, Alcala A, Averbukh M, Dutta N, Moaddeli D, Hicks D, de Los Rios Rogers M, Sahay A, Curran SP, Mullen PJ, Benayoun BA, Garcia G, Higuchi-Sanabria R. Coakley AJ, et al. Among authors: higuchi sanabria r. bioRxiv [Preprint]. 2024 May 30:2024.05.27.595950. doi: 10.1101/2024.05.27.595950. bioRxiv. 2024. PMID: 38854121 Free PMC article. Preprint.
A metabolic atlas of mouse aging.
Pilley SE, Awad D, Latumalea D, Esparza E, Zhang L, Shi X, Unfried M, Wang S, Mulondo R, Kashyap SB, Moaddeli D, Sajjakulnukit P, Sutton D, Wong H, Coakley AJ, Garcia G, Higuchi-Sanabria R, Liu S, Yu B, Tu WB, Kennedy BK, Lyssiotis CA, Mullen PJ. Pilley SE, et al. Among authors: higuchi sanabria r. bioRxiv [Preprint]. 2024 May 5:2024.05.04.592445. doi: 10.1101/2024.05.04.592445. bioRxiv. 2024. PMID: 38746230 Free PMC article. Preprint.
Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.
Oorloff M, Hruby A, Averbukh M, Alcala A, Dutta N, Torres TC, Moaddeli D, Vega M, Kim J, Bong A, Coakley AJ, Hicks D, Wang J, Wang T, Hoang S, Tharp KM, Garcia G, Higuchi-Sanabria R. Oorloff M, et al. Among authors: higuchi sanabria r. bioRxiv [Preprint]. 2024 Apr 12:2024.04.11.589121. doi: 10.1101/2024.04.11.589121. bioRxiv. 2024. Update in: PLoS One. 2024 Sep 12;19(9):e0302673. doi: 10.1371/journal.pone.0302673 PMID: 38645203 Free PMC article. Updated. Preprint.
Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging.
Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Kim J, Torres TC, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. Dutta N, et al. Among authors: higuchi sanabria r. Geroscience. 2024 Dec;46(6):6009-6028. doi: 10.1007/s11357-024-01144-w. Epub 2024 Apr 3. Geroscience. 2024. PMID: 38570396 Free PMC article.
Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging.
Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Castro Torres T, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. Dutta N, et al. Among authors: higuchi sanabria r. bioRxiv [Preprint]. 2023 Nov 27:2023.11.27.568896. doi: 10.1101/2023.11.27.568896. bioRxiv. 2023. PMID: 38077060 Free PMC article. Preprint.
Glial-derived mitochondrial signals affect neuronal proteostasis and aging.
Bar-Ziv R, Dutta N, Hruby A, Sukarto E, Averbukh M, Alcala A, Henderson HR, Durieux J, Tronnes SU, Ahmad Q, Bolas T, Perez J, Dishart JG, Vega M, Garcia G, Higuchi-Sanabria R, Dillin A. Bar-Ziv R, et al. Among authors: higuchi sanabria r. Sci Adv. 2023 Oct 13;9(41):eadi1411. doi: 10.1126/sciadv.adi1411. Epub 2023 Oct 13. Sci Adv. 2023. PMID: 37831769 Free PMC article.
Glial-derived mitochondrial signals impact neuronal proteostasis and aging.
Bar-Ziv R, Dutta N, Hruby A, Sukarto E, Averbukh M, Alcala A, Henderson HR, Durieux J, Tronnes SU, Ahmad Q, Bolas T, Perez J, Dishart JG, Vega M, Garcia G, Higuchi-Sanabria R, Dillin A. Bar-Ziv R, et al. Among authors: higuchi sanabria r. bioRxiv [Preprint]. 2023 Aug 8:2023.07.20.549924. doi: 10.1101/2023.07.20.549924. bioRxiv. 2023. Update in: Sci Adv. 2023 Oct 13;9(41):eadi1411. doi: 10.1126/sciadv.adi1411 PMID: 37609253 Free PMC article. Updated. Preprint.
43 results