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Page 1
Automated design of multi-target ligands by generative deep learning.
Isigkeit L, Hörmann T, Schallmayer E, Scholz K, Lillich FF, Ehrler JHM, Hufnagel B, Büchner J, Marschner JA, Pabel J, Proschak E, Merk D. Isigkeit L, et al. Among authors: ehrler jhm. Nat Commun. 2024 Sep 11;15(1):7946. doi: 10.1038/s41467-024-52060-8. Nat Commun. 2024. PMID: 39261471 Free PMC article.
Compilation and evaluation of a fatty acid mimetics screening library.
Ehrler JHM, Brunst S, Tjaden A, Kilu W, Heering J, Hernandez-Olmos V, Krommes A, Kramer JS, Steinhilber D, Schubert-Zsilavecz M, Müller S, Merk D, Proschak E. Ehrler JHM, et al. Biochem Pharmacol. 2022 Oct;204:115191. doi: 10.1016/j.bcp.2022.115191. Epub 2022 Jul 27. Biochem Pharmacol. 2022. PMID: 35907497
Development of a Potent and Selective G2A (GPR132) Agonist.
Hernandez-Olmos V, Heering J, Marinescu B, Schermeng T, Ivanov VV, Moroz YS, Nevermann S, Mathes M, Ehrler JHM, Alnouri MW, Wolf M, Haydo AS, Schmachtel T, Zaliani A, Höfner G, Kaiser A, Schubert-Zsilavecz M, Beck-Sickinger AG, Offermanns S, Gribbon P, Rieger MA, Merk D, Sisignano M, Steinhilber D, Proschak E. Hernandez-Olmos V, et al. Among authors: ehrler jhm. J Med Chem. 2024 Jul 11;67(13):10567-10588. doi: 10.1021/acs.jmedchem.3c02164. Epub 2024 Jun 25. J Med Chem. 2024. PMID: 38917049
Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells.
Brunst S, Schönfeld J, Breunig P, Burgers LD, DeMeglio M, Ehrler JHM, Lillich FF, Weizel L, Hefendehl JK, Fürst R, Proschak E, Hiesinger K. Brunst S, et al. Among authors: ehrler jhm. ACS Med Chem Lett. 2022 Jun 14;13(7):1062-1067. doi: 10.1021/acsmedchemlett.2c00073. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859883 Free PMC article.
Photosensitization enables Pauson-Khand-type reactions with nitrenes.
Li F, Zhu WF, Empel C, Datsenko O, Kumar A, Xu Y, Ehrler JHM, Atodiresei I, Knapp S, Mykhailiuk PK, Proschak E, Koenigs RM. Li F, et al. Among authors: ehrler jhm. Science. 2024 Feb 2;383(6682):498-503. doi: 10.1126/science.adm8095. Epub 2024 Feb 1. Science. 2024. PMID: 38301027
Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator.
Dötsch L, Davies C, Hennes E, Schönfeld J, Kumar A, Guita CDCL, Ehrler JHM, Hiesinger K, Thavam S, Janning P, Sievers S, Knapp S, Proschak E, Ziegler S, Waldmann H. Dötsch L, et al. Among authors: ehrler jhm. J Med Chem. 2024 Mar 28;67(6):4691-4706. doi: 10.1021/acs.jmedchem.3c02245. Epub 2024 Mar 12. J Med Chem. 2024. PMID: 38470246 Free PMC article.