Metsä-Ketelä M - Search Results

1

Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates.

Mäkinen JJ, Rosenqvist P, Virta P, Metsä-Ketelä M, Belogurov GA. Mäkinen JJ, et al. Among authors: metsa ketela m. J Biol Chem. 2024 Oct;300(10):107755. doi: 10.1016/j.jbc.2024.107755. Epub 2024 Sep 12. J Biol Chem. 2024. PMID: 39260691 Free PMC article.

2

Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE.

Kallio P, Patrikainen P, Belogurov GA, Mäntsälä P, Yang K, Niemi J, Metsä-Ketelä M. Kallio P, et al. Biochemistry. 2013 Jul 2;52(26):4507-16. doi: 10.1021/bi400381s. Epub 2013 Jun 17. Biochemistry. 2013. PMID: 23731237

3

Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics.

Palmu K, Rosenqvist P, Thapa K, Ilina Y, Siitonen V, Baral B, Mäkinen J, Belogurov G, Virta P, Niemi J, Metsä-Ketelä M. Palmu K, et al. ACS Chem Biol. 2017 Jun 16;12(6):1472-1477. doi: 10.1021/acschembio.7b00078. Epub 2017 Apr 27. ACS Chem Biol. 2017. PMID: 28418235 Free article.

4

Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin.

Rosenqvist P, Palmu K, Prajapati RK, Yamada K, Niemi J, Belogurov GA, Metsä-Ketelä M, Virta P. Rosenqvist P, et al. Sci Rep. 2019 Jun 20;9(1):8935. doi: 10.1038/s41598-019-45375-w. Sci Rep. 2019. PMID: 31222036 Free PMC article.

5

Oxazinomycin arrests RNA polymerase at the polythymidine sequences.

Prajapati RK, Rosenqvist P, Palmu K, Mäkinen JJ, Malinen AM, Virta P, Metsä-Ketelä M, Belogurov GA. Prajapati RK, et al. Nucleic Acids Res. 2019 Nov 4;47(19):10296-10312. doi: 10.1093/nar/gkz782. Nucleic Acids Res. 2019. PMID: 31495891 Free PMC article.

6

The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases.

Mäkinen JJ, Shin Y, Vieras E, Virta P, Metsä-Ketelä M, Murakami KS, Belogurov GA. Mäkinen JJ, et al. Nat Commun. 2021 Feb 4;12(1):796. doi: 10.1038/s41467-021-21005-w. Nat Commun. 2021. PMID: 33542236 Free PMC article.

7

The role of the maleimide ring system on the structure-activity relationship of showdomycin.

Rosenqvist P, Mäkinen JJ, Palmu K, Jokinen J, Prajapati RK, Korhonen HJ, Virta P, Belogurov GA, Metsä-Ketelä M. Rosenqvist P, et al. Eur J Med Chem. 2022 Jul 5;237:114342. doi: 10.1016/j.ejmech.2022.114342. Epub 2022 Apr 11. Eur J Med Chem. 2022. PMID: 35439612 Free article.

8

Fluorogenic RNA aptamers to probe transcription initiation and co-transcriptional RNA folding by multi-subunit RNA polymerases.

Huang YH, Trapp V, Puro O, Mäkinen JJ, Metsä-Ketelä M, Wahl MC, Belogurov GA. Huang YH, et al. Methods Enzymol. 2022;675:207-233. doi: 10.1016/bs.mie.2022.07.010. Epub 2022 Aug 19. Methods Enzymol. 2022. PMID: 36220271

9

Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway.

Artukka E, Schnell R, Palmu K, Rosenqvist P, Szodorai E, Niemi J, Virta P, Schneider G, Metsä-Ketelä M. Artukka E, et al. Among authors: metsa ketela m. ACS Chem Biol. 2023 Apr 21;18(4):794-802. doi: 10.1021/acschembio.2c00826. Epub 2023 Apr 2. ACS Chem Biol. 2023. PMID: 37005433 Free PMC article.

10

Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.

Oja T, Palmu K, Lehmussola H, Leppäranta O, Hännikäinen K, Niemi J, Mäntsälä P, Metsä-Ketelä M. Oja T, et al. Chem Biol. 2008 Oct 20;15(10):1046-57. doi: 10.1016/j.chembiol.2008.07.022. Chem Biol. 2008. PMID: 18940666

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