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Page 1
A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system.
Costacurta F, Dodaro A, Bante D, Schöppe H, Peng JY, Sprenger B, He X, Moghadasi SA, Egger LM, Fleischmann J, Pavan M, Bassani D, Menin S, Rauch S, Krismer L, Sauerwein A, Heberle A, Rabensteiner T, Ho J, Harris RS, Stefan E, Schneider R, Dunzendorfer-Matt T, Naschberger A, Wang D, Kaserer T, Moro S, von Laer D, Heilmann E. Costacurta F, et al. Among authors: stefan e. PLoS Pathog. 2024 Sep 11;20(9):e1012522. doi: 10.1371/journal.ppat.1012522. eCollection 2024 Sep. PLoS Pathog. 2024. PMID: 39259728 Free PMC article.
A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system.
Costacurta F, Dodaro A, Bante D, Schöppe H, Sprenger B, Moghadasi SA, Fleischmann J, Pavan M, Bassani D, Menin S, Rauch S, Krismer L, Sauerwein A, Heberle A, Rabensteiner T, Ho J, Harris RS, Stefan E, Schneider R, Kaserer T, Moro S, von Laer D, Heilmann E. Costacurta F, et al. Among authors: stefan e. bioRxiv [Preprint]. 2023 Oct 4:2023.09.22.558628. doi: 10.1101/2023.09.22.558628. bioRxiv. 2023. Update in: PLoS Pathog. 2024 Sep 11;20(9):e1012522. doi: 10.1371/journal.ppat.1012522 PMID: 37808638 Free PMC article. Updated. Preprint.
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, Dror RO, Evers AS, Mukhopadhyay S, Manglik A. Hoppe N, et al. Among authors: stefan e. bioRxiv [Preprint]. 2023 May 24:2023.05.23.540554. doi: 10.1101/2023.05.23.540554. bioRxiv. 2023. Update in: Nat Struct Mol Biol. 2024 Apr;31(4):667-677. doi: 10.1038/s41594-024-01223-8 PMID: 37292845 Free PMC article. Updated. Preprint.
A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species.
Benjamin-Zukerman T, Shimon G, Gaine ME, Dakwar A, Peled N, Aboraya M, Masri-Ismail A, Safadi-Safa R, Solomon M, Lev-Ram V, Rissman RA, Mayrhofer JE, Raffeiner A, Mol MO, Argue BMR, McCool S, Doan B, van Swieten J, Stefan E, Abel T, Ilouz R. Benjamin-Zukerman T, et al. Among authors: stefan e. Brain. 2024 Nov 4;147(11):3890-3905. doi: 10.1093/brain/awae154. Brain. 2024. PMID: 38743596 Free PMC article.
Activation of parkin by a molecular glue.
Sauvé V, Stefan E, Croteau N, Goiran T, Fakih R, Bansal N, Hadzipasic A, Fang J, Murugan P, Chen S, Fon EA, Hirst WD, Silvian LF, Trempe JF, Gehring K. Sauvé V, et al. Among authors: stefan e. Nat Commun. 2024 Sep 19;15(1):7707. doi: 10.1038/s41467-024-51889-3. Nat Commun. 2024. PMID: 39300082 Free PMC article.
Impact of protein and small molecule interactions on kinase conformations.
Kugler V, Schwaighofer S, Feichtner A, Enzler F, Fleischmann J, Strich S, Schwarz S, Wilson R, Tschaikner P, Troppmair J, Sexl V, Meier P, Kaserer T, Stefan E. Kugler V, et al. Among authors: stefan e. Elife. 2024 Aug 1;13:RP94755. doi: 10.7554/eLife.94755. Elife. 2024. PMID: 39088265 Free PMC article.
Author Correction: Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system.
Rinaldi L, Donne RD, Catalanotti B, Torres-Quesada O, Enzler F, Moraca F, Nisticò R, Chiuso F, Piccinin S, Bachmann V, Lindner HH, Garbi C, Scorziello A, Russo NA, Synofzik M, Stelzl U, Annunziato L, Stefan E, Feliciello A. Rinaldi L, et al. Among authors: stefan e. Nat Commun. 2024 May 29;15(1):4565. doi: 10.1038/s41467-024-49118-y. Nat Commun. 2024. PMID: 38811561 Free PMC article. No abstract available.
BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.
Meibom D, Wasnaire P, Beyer K, Broehl A, Cancho-Grande Y, Elowe N, Henninger K, Johannes S, Jungmann N, Krainz T, Lindner N, Maassen S, MacDonald B, Menshykau D, Mittendorf J, Sanchez G, Schaefer M, Stefan E, Torge A, Xing Y, Zubov D. Meibom D, et al. Among authors: stefan e. J Med Chem. 2024 Feb 22;67(4):2907-2940. doi: 10.1021/acs.jmedchem.3c02036. Epub 2024 Feb 13. J Med Chem. 2024. PMID: 38348661 Free PMC article.
94 results