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Mitochondrial RNA cytosolic leakage drives the SASP.
Victorelli S, Eppard M, Woo SH, Everts SPA, Martini H, Pirius N, Franco AC, Han Y, Saul D, Splinter PL, O'Hara SP, Valenzuela-Pérez L, Lee HSK, Jurk D, LaRusso NF, Hirsova P, Passos JF. Victorelli S, et al. Among authors: splinter pl. Res Sq [Preprint]. 2024 Aug 27:rs.3.rs-4876596. doi: 10.21203/rs.3.rs-4876596/v1. Res Sq. 2024. PMID: 39257994 Free PMC article. Preprint.
The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.
O'Hara SP, Splinter PL, Trussoni CE, Guicciardi ME, Splinter NP, Al Suraih MS, Nasser-Ghodsi N, Stollenwerk D, Gores GJ, LaRusso NF. O'Hara SP, et al. Among authors: splinter pl. J Biol Chem. 2019 Dec 6;294(49):18698-18713. doi: 10.1074/jbc.RA119.010176. Epub 2019 Oct 28. J Biol Chem. 2019. PMID: 31659122 Free PMC article.
Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice.
Guicciardi ME, Trussoni CE, Krishnan A, Bronk SF, Lorenzo Pisarello MJ, O'Hara SP, Splinter PL, Gao Y, Vig P, Revzin A, LaRusso NF, Gores GJ. Guicciardi ME, et al. Among authors: splinter pl. J Hepatol. 2018 Sep;69(3):676-686. doi: 10.1016/j.jhep.2018.05.018. Epub 2018 May 24. J Hepatol. 2018. PMID: 29802947 Free PMC article.
Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.
Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, LaRusso NF, Mertens JC. Moncsek A, et al. Among authors: splinter pl. Hepatology. 2018 Jan;67(1):247-259. doi: 10.1002/hep.29464. Epub 2017 Nov 29. Hepatology. 2018. PMID: 28802066 Free PMC article.
52 results