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226 results

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Page 1
Mitochondrial RNA cytosolic leakage drives the SASP.
Victorelli S, Eppard M, Woo SH, Everts SPA, Martini H, Pirius N, Franco AC, Han Y, Saul D, Splinter PL, O'Hara SP, Valenzuela-Pérez L, Lee HSK, Jurk D, LaRusso NF, Hirsova P, Passos JF. Victorelli S, et al. Among authors: saul d. Res Sq [Preprint]. 2024 Aug 27:rs.3.rs-4876596. doi: 10.21203/rs.3.rs-4876596/v1. Res Sq. 2024. PMID: 39257994 Free PMC article. Preprint.
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: saul d. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: saul d. Nature. 2024 Jan;625(7995):E15. doi: 10.1038/s41586-023-07002-7. Nature. 2024. PMID: 38168624 Free PMC article. No abstract available.
Distinct secretomes in p16- and p21- positive senescent cells across tissues.
Saul D, Jurk D, Doolittle ML, Kosinsky RL, Monroe DG, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Khosla S, Passos JF. Saul D, et al. bioRxiv [Preprint]. 2023 Dec 5:2023.12.05.569858. doi: 10.1101/2023.12.05.569858. bioRxiv. 2023. PMID: 38106149 Free PMC article. Preprint.
Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair.
Saul D, Doolittle ML, Rowsey JL, Froemming MN, Kosinsky RL, Vos SJ, Ruan M, LeBrasseur N, Chandra A, Pignolo R, Passos JF, Farr JN, Monroe DG, Khosla S. Saul D, et al. bioRxiv [Preprint]. 2024 Feb 7:2024.02.01.578420. doi: 10.1101/2024.02.01.578420. bioRxiv. 2024. Update in: J Clin Invest. 2024 May 16;134(12):e179834. doi: 10.1172/JCI179834 PMID: 38370844 Free PMC article. Updated. Preprint.
Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.
Kim Y, Kim SW, Saul D, Neyazi M, Schmid M, Wakimoto H, Slaven N, Lee JH, Layton OG, Wasson LK, Letendre JH, Xiao F, Ewoldt JK, Gkatzis K, Sommer P, Gobert B, Wiest-Daesslé N, McAfee Q, Singhal N, Lun M, Gorham JM, Arany Z, Sharma A, Toepfer CN, Oudit GY, Pu WT, Dickel DE, Pennacchio LA, Visel A, Chen CS, Seidman JG, Seidman CE. Kim Y, et al. Among authors: saul d. J Clin Invest. 2024 Dec 17:e183353. doi: 10.1172/JCI183353. Online ahead of print. J Clin Invest. 2024. PMID: 39688912 Free article.
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial.
Farr JN, Atkinson EJ, Achenbach SJ, Volkman TL, Tweed AJ, Vos SJ, Ruan M, Sfeir J, Drake MT, Saul D, Doolittle ML, Bancos I, Yu K, Tchkonia T, LeBrasseur NK, Kirkland JL, Monroe DG, Khosla S. Farr JN, et al. Among authors: saul d. Nat Med. 2024 Sep;30(9):2605-2612. doi: 10.1038/s41591-024-03096-2. Epub 2024 Jul 2. Nat Med. 2024. PMID: 38956196 Clinical Trial.
226 results