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Chlamydia trachomatis induces low-frequency, sustained CD4 T cell responses in most women, predominantly targeting chlamydial protease-like activity factor, CPAF.
Li Y, Warren JA, Poston TB, Clutton G, Shaw FR, Conrad SZ, Xu Y, Zheng X, Yount KS, O'Connell CM, Wiesenfeld HC, Darville T, Goonetilleke N. Li Y, et al. Among authors: xu y. J Infect Dis. 2024 Sep 9:jiae443. doi: 10.1093/infdis/jiae443. Online ahead of print. J Infect Dis. 2024. PMID: 39250505
CD3 downregulation identifies high-avidity human CD8 T cells.
Clutton GT, Weideman AMK, Mischell MA, Kallon S, Conrad SZ, Shaw FR, Warren JA, Lin L, Kuruc JD, Xu Y, Gay CM, Armistead PM, G Hudgens M, Goonetilleke NP. Clutton GT, et al. Among authors: xu y. Clin Exp Immunol. 2024 Feb 19;215(3):279-290. doi: 10.1093/cei/uxad124. Clin Exp Immunol. 2024. PMID: 37950348 Free PMC article.
HIV-Specific T Cell Responses Are Highly Stable on Antiretroviral Therapy.
Xu Y, Trumble IM, Warren JA, Clutton G, Abad-Fernandez M, Kirchnerr J, Adimora AA, Deeks SG, Margolis DM, Kuruc JD, Gay CL, Archin NM, Mollan KR, Hudgens M, Goonetilleke N. Xu Y, et al. Mol Ther Methods Clin Dev. 2019 Aug 14;15:9-17. doi: 10.1016/j.omtm.2019.07.008. eCollection 2019 Dec 13. Mol Ther Methods Clin Dev. 2019. PMID: 31534983 Free PMC article.
Sequence Analysis of Inducible, Replication-Competent Virus Reveals No Evidence of HIV-1 Evolution During Suppressive Antiviral Therapy, Indicating a Lack of Ongoing Viral Replication.
Lee SK, Sondgeroth A, Xu Y, Warren J, Zhou S, Gilleece M, Hauser BM, Gay CL, Kuruc JD, Archin NM, Eron JJ, Margolis DM, Goonetilleke N, Swanstrom R. Lee SK, et al. Among authors: xu y. Open Forum Infect Dis. 2024 Apr 17;11(5):ofae212. doi: 10.1093/ofid/ofae212. eCollection 2024 May. Open Forum Infect Dis. 2024. PMID: 38756763 Free PMC article.
Reliable Estimation of CD8 T Cell Inhibition of In Vitro HIV-1 Replication.
Xu Y, Weideman AM, Abad-Fernandez M, Mollan KR, Kallon S, Samir S, Warren JA, Clutton G, Roan NR, Adimora AA, Archin N, Kuruc J, Gay C, Hudgens MG, Goonetilleke N. Xu Y, et al. Front Immunol. 2021 Jun 30;12:666991. doi: 10.3389/fimmu.2021.666991. eCollection 2021. Front Immunol. 2021. PMID: 34276657 Free PMC article.
CD8 T Cell Virus Inhibition Assay Protocol.
Xu Y, Weideman AM, Abad-Fernandez M, Mollan KR, Kallon S, Samir S, Warren JA, Clutton G, Roan N, Adimora AA, Archin N, Kuruc J, Gay C, Hudgens MG, Goonetilleke N. Xu Y, et al. Bio Protoc. 2022 Mar 20;12(6):e4354. doi: 10.21769/BioProtoc.4354. eCollection 2022 Mar 20. Bio Protoc. 2022. PMID: 35434196 Free PMC article.
Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency.
Archin NM, Kirchherr JL, Sung JA, Clutton G, Sholtis K, Xu Y, Allard B, Stuelke E, Kashuba AD, Kuruc JD, Eron J, Gay CL, Goonetilleke N, Margolis DM. Archin NM, et al. Among authors: xu y. J Clin Invest. 2017 Aug 1;127(8):3126-3135. doi: 10.1172/JCI92684. Epub 2017 Jul 17. J Clin Invest. 2017. PMID: 28714868 Free PMC article.
Corrigendum: Reliable estimation of CD8 T cell inhibition of in vitro HIV-1 replication.
Xu Y, Weideman AM, Abad-Fernandez M, Mollan KR, Kallon S, Samir S, Warren JA, Clutton G, Roan NR, Adimora AA, Archin N, Kuruc J, Gay C, Hudgens MG, Goonetilleke N. Xu Y, et al. Front Immunol. 2023 Jan 3;13:1104661. doi: 10.3389/fimmu.2022.1104661. eCollection 2022. Front Immunol. 2023. PMID: 36685544 Free PMC article.
The HIV-1 latent reservoir is largely sensitive to circulating T cells.
Warren JA, Zhou S, Xu Y, Moeser MJ, MacMillan DR, Council O, Kirchherr J, Sung JM, Roan NR, Adimora AA, Joseph S, Kuruc JD, Gay CL, Margolis DM, Archin N, Brumme ZL, Swanstrom R, Goonetilleke N. Warren JA, et al. Among authors: xu y. Elife. 2020 Oct 6;9:e57246. doi: 10.7554/eLife.57246. Elife. 2020. PMID: 33021198 Free PMC article.
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