Abdel-Aziz HA - Search Results

1

Development of new LSM-83177 analogues as anti-tumor agents against colorectal cancer targeting p53-MDM2 interaction.

Elgohary MK, Elkotamy MS, Al-Warhi T, Eldehna WM, Abdel-Aziz HA. Elgohary MK, et al. Bioorg Chem. 2024 Dec;153:107766. doi: 10.1016/j.bioorg.2024.107766. Epub 2024 Aug 28. Bioorg Chem. 2024. PMID: 39244969

2

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens.

Al-Warhi T, Elimam DM, Elsayed ZM, Abdel-Aziz MM, Maklad RM, Al-Karmalawy AA, Afarinkia K, Abourehab MAS, Abdel-Aziz HA, Eldehna WM. Al-Warhi T, et al. RSC Adv. 2022 Nov 2;12(48):31466-31477. doi: 10.1039/d2ra04385h. eCollection 2022 Oct 27. RSC Adv. 2022. PMID: 36382148 Free PMC article.

3

WRH-2412 alleviates the progression of hepatocellular carcinoma through regulation of TGF-β/β-catenin/α-SMA pathway.

Elewa MAF, Eldehna WM, Hamdan AME, Abd El-Kawi SH, El-Kalaawy AM, Majrashi TA, Barghash RF, Abdel-Aziz HA, Hashem KS, Al-Gayyar MMH. Elewa MAF, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2185761. doi: 10.1080/14756366.2023.2185761. J Enzyme Inhib Med Chem. 2023. PMID: 36912230 Free PMC article.

4

Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer.

Eldehna WM, Mohammed EE, Al-Ansary GH, Berrino E, Elbadawi MM, Ibrahim TM, Jaballah MY, Al-Rashood ST, Binjubair FA, Celik M, Nocentini A, Elbarbry FA, Sahin F, Abdel-Aziz HA, Supuran CT, Fares M. Eldehna WM, et al. Eur J Med Chem. 2023 Oct 5;258:115538. doi: 10.1016/j.ejmech.2023.115538. Epub 2023 Jun 1. Eur J Med Chem. 2023. PMID: 37321108

5

Fragment merging approach for the design of thiazole/thiazolidine clubbed pyrazoline derivatives as anti-inflammatory agents: Synthesis, biopharmacological evaluation and molecular modeling studies.

Elgohary MK, Abd El Hadi SR, Abo-Ashour MF, Abo-El Fetoh ME, Afify H, Abdel-Aziz HA, Abou-Seri SM. Elgohary MK, et al. Bioorg Chem. 2023 Oct;139:106724. doi: 10.1016/j.bioorg.2023.106724. Epub 2023 Jul 8. Bioorg Chem. 2023. PMID: 37451146

6

1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR-2 Inhibitory Activities.

Elsawi AE, Elbadawi MM, Nocentini A, Almahli H, Giovannuzzi S, Shaldam M, Salem R, Ibrahim TM, Abdel-Aziz HA, Supuran CT, Eldehna WM. Elsawi AE, et al. J Med Chem. 2023 Aug 10;66(15):10558-10578. doi: 10.1021/acs.jmedchem.3c00721. Epub 2023 Jul 27. J Med Chem. 2023. PMID: 37501287

7

Design, Synthesis and Biological Assessment of N'-(2-Oxoindolin-3-ylidene)-6-methylimidazo[2,1-b]thiazole-5-carbohydrazides as Potential Anti-Proliferative Agents toward MCF-7 Breast Cancer.

Alshaye NA, Elgohary MK, Elkotamy MS, Abdel-Aziz HA. Alshaye NA, et al. Pharmaceuticals (Basel). 2024 Feb 7;17(2):216. doi: 10.3390/ph17020216. Pharmaceuticals (Basel). 2024. PMID: 38399431 Free PMC article.

8

Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer's disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation.

Abdo Moustafa E, Abdelrasheed Allam H, Fouad MA, El Kerdawy AM, Nasser Eid El-Sayed N, Wagner C, Abdel-Aziz HA, Abdel Fattah Ezzat M. Abdo Moustafa E, et al. Bioorg Chem. 2024 May;146:107324. doi: 10.1016/j.bioorg.2024.107324. Epub 2024 Mar 30. Bioorg Chem. 2024. PMID: 38569322

9

Fenamates and ibuprofen as foundational components in the synthesis of innovative, targeted COX-2 anti-inflammatory drugs, undergoing thorough biopharmacological assessments and in-silico computational studies.

Elgohary MK, Elkotamy MS, Abdelrahman Alkabbani M, Abdel-Aziz HA. Elgohary MK, et al. Bioorg Chem. 2024 Jun;147:107393. doi: 10.1016/j.bioorg.2024.107393. Epub 2024 Apr 24. Bioorg Chem. 2024. PMID: 38691908

10

Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments.

Elsebaie HA, Abdulla MH, Elsayed ZM, Shaldam MA, Tawfik HO, Morsy SN, Vaali Mohammed MA, Bin Traiki T, Elkaeed EB, Abdel-Aziz HA, Eldehna WM. Elsebaie HA, et al. Bioorg Chem. 2024 Oct;151:107626. doi: 10.1016/j.bioorg.2024.107626. Epub 2024 Jul 10. Bioorg Chem. 2024. PMID: 39013242

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