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Eggshell membrane and its major component lysozyme and ovotransferrin enhance the secretion of decorin as an endogenous antifibrotic mediator from lung fibroblasts and ameliorate bleomycin-induced pulmonary fibrosis.
Ohto-Fujita E, Shimizu M, Atomi A, Hiruta H, Hosoda R, Horinouchi S, Miyazaki S, Murakami T, Asano Y, Hasebe Y, Atomi Y. Ohto-Fujita E, et al. Among authors: asano y. Biochem Biophys Rep. 2024 Aug 12;39:101806. doi: 10.1016/j.bbrep.2024.101806. eCollection 2024 Sep. Biochem Biophys Rep. 2024. PMID: 39234595 Free PMC article.
Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target.
Marangoni RG, Masui Y, Fang F, Korman B, Lord G, Lee J, Lakota K, Wei J, Scherer PE, Otvos L, Yamauchi T, Kubota N, Kadowaki T, Asano Y, Sato S, Tourtellotte WG, Varga J. Marangoni RG, et al. Among authors: asano y. Sci Rep. 2017 Jun 30;7(1):4397. doi: 10.1038/s41598-017-04162-1. Sci Rep. 2017. PMID: 28667272 Free PMC article.
CXCL13 produced by macrophages due to Fli1 deficiency may contribute to the development of tissue fibrosis, vasculopathy and immune activation in systemic sclerosis.
Taniguchi T, Miyagawa T, Toyama S, Yamashita T, Nakamura K, Saigusa R, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sato S, Asano Y. Taniguchi T, et al. Among authors: asano y. Exp Dermatol. 2018 Sep;27(9):1030-1037. doi: 10.1111/exd.13724. Epub 2018 Jul 29. Exp Dermatol. 2018. PMID: 29947047
2,561 results