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Page 1
Syk inhibitors reduce tau protein phosphorylation and oligomerization.
Yamaguchi T, Hamano T, Sada K, Asano R, Kanaan NM, Sasaki H, Yen SH, Kitazaki Y, Endo Y, Enomoto S, Shirafuji N, Ikawa M, Yamamura O, Fujita Y, Aoki K, Naiki H, Morishima M, Saito Y, Murayama S, Nakamoto Y. Yamaguchi T, et al. Among authors: kanaan nm. Neurobiol Dis. 2024 Oct 15;201:106656. doi: 10.1016/j.nbd.2024.106656. Epub 2024 Sep 2. Neurobiol Dis. 2024. PMID: 39233131 Free article.
Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization.
Shirafuji N, Hamano T, Yen SH, Kanaan NM, Yoshida H, Hayashi K, Ikawa M, Yamamura O, Kuriyama M, Nakamoto Y. Shirafuji N, et al. Among authors: kanaan nm. Int J Mol Sci. 2018 Mar 17;19(3):891. doi: 10.3390/ijms19030891. Int J Mol Sci. 2018. PMID: 29562600 Free PMC article.
Rho-kinase ROCK inhibitors reduce oligomeric tau protein.
Hamano T, Shirafuji N, Yen SH, Yoshida H, Kanaan NM, Hayashi K, Ikawa M, Yamamura O, Fujita Y, Kuriyama M, Nakamoto Y. Hamano T, et al. Among authors: kanaan nm. Neurobiol Aging. 2020 May;89:41-54. doi: 10.1016/j.neurobiolaging.2019.12.009. Epub 2019 Dec 16. Neurobiol Aging. 2020. PMID: 31982202 Free PMC article.
Pioglitazone prevents tau oligomerization.
Hamano T, Shirafuji N, Makino C, Yen SH, Kanaan NM, Ueno A, Suzuki J, Ikawa M, Matsunaga A, Yamamura O, Kuriyama M, Nakamoto Y. Hamano T, et al. Among authors: kanaan nm. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1035-42. doi: 10.1016/j.bbrc.2016.08.016. Epub 2016 Aug 16. Biochem Biophys Res Commun. 2016. PMID: 27543203
Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein.
Lin G, Zhu F, Kanaan NM, Asano R, Shirafuji N, Sasaki H, Yamaguchi T, Enomoto S, Endo Y, Ueno A, Ikawa M, Hayashi K, Yamamura O, Yen SH, Nakamoto Y, Hamano T. Lin G, et al. Among authors: kanaan nm. Int J Mol Sci. 2021 Nov 8;22(21):12063. doi: 10.3390/ijms222112063. Int J Mol Sci. 2021. PMID: 34769495 Free PMC article.
Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease.
Tiernan CT, Ginsberg SD, He B, Ward SM, Guillozet-Bongaarts AL, Kanaan NM, Mufson EJ, Counts SE. Tiernan CT, et al. Among authors: kanaan nm. Neurobiol Dis. 2018 Sep;117:125-136. doi: 10.1016/j.nbd.2018.05.021. Epub 2018 May 31. Neurobiol Dis. 2018. PMID: 29859871 Free PMC article.
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration.
Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, Lee VM, Sortwell CE. Paumier KL, et al. Among authors: kanaan nm. Neurobiol Dis. 2015 Oct;82:185-199. doi: 10.1016/j.nbd.2015.06.003. Epub 2015 Jun 17. Neurobiol Dis. 2015. PMID: 26093169 Free PMC article.
81 results