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TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation.
Mühlgrabner V, Peters T, Velasco Cárdenas RM, Salzer B, Göhring J, Plach A, Höhrhan M, Perez ID, Goncalves VDR, Farfán JS, Lehner M, Stockinger H, Schamel WW, Schober K, Busch DH, Hudecek M, Dushek O, Minguet S, Platzer R, Huppa JB. Mühlgrabner V, et al. Among authors: huppa jb. Sci Adv. 2024 Sep 6;10(36):eadj4632. doi: 10.1126/sciadv.adj4632. Epub 2024 Sep 4. Sci Adv. 2024. PMID: 39231214 Free PMC article.
Harnessing CD3 diversity to optimize CAR T cells.
Velasco Cárdenas RM, Brandl SM, Meléndez AV, Schlaak AE, Buschky A, Peters T, Beier F, Serrels B, Taromi S, Raute K, Hauri S, Gstaiger M, Lassmann S, Huppa JB, Boerries M, Andrieux G, Bengsch B, Schamel WW, Minguet S. Velasco Cárdenas RM, et al. Among authors: huppa jb. Nat Immunol. 2023 Dec;24(12):2135-2149. doi: 10.1038/s41590-023-01658-z. Epub 2023 Nov 6. Nat Immunol. 2023. PMID: 37932456 Free PMC article.
Monomeric TCRs drive T cell antigen recognition.
Brameshuber M, Kellner F, Rossboth BK, Ta H, Alge K, Sevcsik E, Göhring J, Axmann M, Baumgart F, Gascoigne NRJ, Davis SJ, Stockinger H, Schütz GJ, Huppa JB. Brameshuber M, et al. Among authors: huppa jb. Nat Immunol. 2018 May;19(5):487-496. doi: 10.1038/s41590-018-0092-4. Epub 2018 Apr 16. Nat Immunol. 2018. PMID: 29662172 Free PMC article.
Inefficient CAR-proximal signaling blunts antigen sensitivity.
Gudipati V, Rydzek J, Doel-Perez I, Gonçalves VDR, Scharf L, Königsberger S, Lobner E, Kunert R, Einsele H, Stockinger H, Hudecek M, Huppa JB. Gudipati V, et al. Among authors: huppa jb. Nat Immunol. 2020 Aug;21(8):848-856. doi: 10.1038/s41590-020-0719-0. Epub 2020 Jul 6. Nat Immunol. 2020. PMID: 32632291
Mechanosurveillance: Tiptoeing T Cells.
Göhring J, Schrangl L, Schütz GJ, Huppa JB. Göhring J, et al. Among authors: huppa jb. Front Immunol. 2022 May 26;13:886328. doi: 10.3389/fimmu.2022.886328. eCollection 2022. Front Immunol. 2022. PMID: 35693808 Free PMC article. Review.
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells.
Horkova V, Drobek A, Paprckova D, Niederlova V, Prasai A, Uleri V, Glatzova D, Kraller M, Cesnekova M, Janusova S, Salyova E, Tsyklauri O, Kadlecek TA, Krizova K, Platzer R, Schober K, Busch DH, Weiss A, Huppa JB, Stepanek O. Horkova V, et al. Among authors: huppa jb. Nat Immunol. 2023 Jan;24(1):174-185. doi: 10.1038/s41590-022-01366-0. Epub 2022 Dec 23. Nat Immunol. 2023. PMID: 36564464 Free PMC article.
Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion.
Platzer R, Hellmeier J, Göhring J, Perez ID, Schatzlmaier P, Bodner C, Focke-Tejkl M, Schütz GJ, Sevcsik E, Stockinger H, Brameshuber M, Huppa JB. Platzer R, et al. Among authors: huppa jb. EMBO Rep. 2023 Nov 6;24(11):e57842. doi: 10.15252/embr.202357842. Epub 2023 Sep 28. EMBO Rep. 2023. PMID: 37768718 Free PMC article.
Measurement of Forces Acting on Single T-Cell Receptors.
Schrangl L, Göhring J, Kellner F, Huppa JB, Schütz GJ. Schrangl L, et al. Among authors: huppa jb. Methods Mol Biol. 2024;2800:147-165. doi: 10.1007/978-1-0716-3834-7_11. Methods Mol Biol. 2024. PMID: 38709483
78 results